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hflD [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945693, updated on 24-Aug-2024

Summary

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Official Symbol
hflD
Primary source
ASAP:ABE-0003812
Locus tag
b1132
See related
ECOCYC:EG11345
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1118; hslZ; ycfC
Summary
hflD is a non-essential gene. [More information is available at EcoGene: EG11345]. hflD belongs to an operon with purB, which is involved in methionine synthesis . hflD encodes an inner membrane-localized protein responsible for directly interacting with protein CII of bacteriophage , making it more vulnerable to proteolysis by FtsH, leading to increased lysogenization frequency of . [More information is available at EcoCyc: EG11345].
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Genomic context

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Sequence:
NC_000913.3 (1191990..1192631, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene sensor histidine kinase PhoQ Neighboring gene DNA-binding transcriptional dual regulator PhoP Neighboring gene adenylosuccinate lyase Neighboring gene tRNA-specific 2-thiouridylase Neighboring gene phosphatase NudJ

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. HflD, an Escherichia coli protein involved in the lambda lysis-lysogeny switch, impairs transcription activation by lambdaCII. Parua PK, et al. Arch Biochem Biophys, 2010 Jan 15. PMID 19853572
  2. Revisiting the lysogenization control of bacteriophage lambda. Identification and characterization of a new host component, HflD. Kihara A, et al. J Biol Chem, 2001 Apr 27. PMID 11278968
  3. The purB gene of Escherichia coli K-12 is located in an operon. Green SM, et al. Microbiology (Reading), 1996 Nov. PMID 8969519
  4. Escherichia coli purB gene: cloning, nucleotide sequence, and regulation by purR. He B, et al. J Bacteriol, 1992 Jan. PMID 1729205, Free PMC Article
  5. Autoregulation of PurR repressor synthesis and involvement of purR in the regulation of purB, purC, purL, purMN and guaBA expression in Escherichia coli. Meng LM, et al. Eur J Biochem, 1990 Jan 26. PMID 2404765

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to heat IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lysogenization regulator

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1191990..1192631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415650.1 lysogenization regulator [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415650.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376MAZ3, A0A5B9AKR3
    Conserved Domains (1) summary
    PRK00218
    Location:1 → 209
    PRK00218; lysogenization regulator HflD
Nucleotide Protein
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