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lolE lipoprotein release complex - inner membrane subunit [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945665, updated on 10-Oct-2024

Summary

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Official Symbol
lolE
Official Full Name
lipoprotein release complex - inner membrane subunit
Primary source
ECOCYC:G6575
Locus tag
b1118
See related
ASAP:ABE-0003776
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1104; ycfW
Summary
LolE is a membrane component of the LolCDE lipoprotein export ABC transporter. [More information is available at EcoCyc: G6575].
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Genomic context

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Sequence:
NC_000913.3 (1177320..1178564)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene inner membrane protein YcfT Neighboring gene lipoprotein release complex - inner membrane subunit Neighboring gene lipoprotein release complex - ATP binding subunit Neighboring gene N-acetyl-D-glucosamine kinase Neighboring gene CobB-S;protein-lysine deacetylase/desuccinylase/lipoamidase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptional Responses of Escherichia coli to a Small-Molecule Inhibitor of LolCDE, an Essential Component of the Lipoprotein Transport Pathway. Lorenz C, et al. J Bacteriol, 2016 Dec 1. PMID 27645386, Free PMC Article
  2. A single amino acid determinant of the membrane localization of lipoproteins in E. coli. Yamaguchi K, et al. Cell, 1988 May 6. PMID 3284654
  3. Biogenesis of the gram-negative bacterial envelope. Duong F, et al. Cell, 1997 Nov 28. PMID 9393850
  4. A new ABC transporter mediating the detachment of lipid-modified proteins from membranes. Yakushi T, et al. Nat Cell Biol, 2000 Apr. PMID 10783239
  5. Disruption of lolCDE, encoding an ATP-binding cassette transporter, is lethal for Escherichia coli and prevents release of lipoproteins from the inner membrane. Narita S, et al. J Bacteriol, 2002 Mar. PMID 11844772, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural basis for bacterial lipoprotein relocation by the transporter LolCDE.
    Title: Structural basis for bacterial lipoprotein relocation by the transporter LolCDE.
  2. Inhibition of LolCDE leads to significant inhibition of growth and lipoprotein transport.
    Title: Transcriptional Responses of Escherichia coli to a Small-Molecule Inhibitor of LolCDE, an Essential Component of the Lipoprotein Transport Pathway.
  3. These results indicate that the affinity of LolCDE for apolipoprotein is very low, and therefore, overexpression of LolCDE is required for its release and sorting to the outer membrane.
    Title: Overexpression of LolCDE allows deletion of the Escherichia coli gene encoding apolipoprotein N-acyltransferase.
  4. N-terminus verified by Edman degradation on mature peptide
    Title: A new ABC transporter mediating the detachment of lipid-modified proteins from membranes.
  5. suppressor mutations of the lolE gene that correct the growth defect caused by the LolD mutations were mainly located in the cytoplasmic loop
    Title: Genetic analysis of the mode of interplay between an ATPase subunit and membrane subunits of the lipoprotein-releasing ATP-binding cassette transporter LolCDE.
  6. Liganded LolCDE thus reveals molecular events brought about through ATP binding and hydrolysis, LolCDE is the first example of an ABC transporter purified with tightly bound native substrates.
    Title: A novel ligand bound ABC transporter, LolCDE, provides insights into the molecular mechanisms underlying membrane detachment of bacterial lipoproteins.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables lipoprotein releasing activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lipoprotein releasing activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipoprotein localization to outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipoprotein localization to outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipoprotein localization to outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lipoprotein localization to outer membrane IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipoprotein localization to outer membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipoprotein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 
part_of plasma membrane protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of plasma membrane protein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
lipoprotein release complex - inner membrane subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1177320..1178564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415636.1 lipoprotein release complex - inner membrane subunit [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415636.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0A0G274, A0A0H3ET60, A0A7U9J0F3, A0AAN3UZK3
    Conserved Domains (1) summary
    PRK11146
    Location:3 → 414
    PRK11146; lipoprotein-releasing ABC transporter permease subunit LolE
Nucleotide Protein
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