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rarA replication-associated recombination protein A [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945505, updated on 10-Oct-2024

Summary

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Official Symbol
rarA
Official Full Name
replication-associated recombination protein A
Primary source
ECOCYC:EG12690
Locus tag
b0892
See related
ASAP:ABE-0003034
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0883; mgsA; ycaJ
Summary
AFMB Structural Genomics target Number 8 (http://afmb.cnrs-mrs.fr/article171. [More information is available at EcoGene: EG12690]. The RarA protein may play a role in recombination associated with DNA replication. [More information is available at EcoCyc: EG12690].
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Genomic context

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Sequence:
NC_000913.3 (937994..939337)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cell division DNA translocase FtsK Neighboring gene outer membrane lipoprotein carrier protein Neighboring gene serine--tRNA ligase Neighboring gene dimethyl sulfoxide reductase subunit A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RecA-independent recombination: Dependence on the Escherichia coli RarA protein. Jain K, et al. Mol Microbiol, 2021 Jun. PMID 33247976, Free PMC Article
  2. DNA flap creation by the RarA/MgsA protein of Escherichia coli. Stanage TH, et al. Nucleic Acids Res, 2017 Mar 17. PMID 28053120, Free PMC Article
  3. Cloning and characterization of the gene for Escherichia coli seryl-tRNA synthetase. Härtlein M, et al. Nucleic Acids Res, 1987 Feb 11. PMID 3029694, Free PMC Article
  4. Escherichia coli DNA polymerase III tau- and gamma-subunit conserved residues required for activity in vivo and in vitro. Walker JR, et al. J Bacteriol, 2000 Nov. PMID 11029431, Free PMC Article
  5. Recombination and chromosome segregation. Sherratt DJ, et al. Philos Trans R Soc Lond B Biol Sci, 2004 Jan 29. PMID 15065657, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The rarA gene as part of an expanded RecFOR recombination pathway: Negative epistasis and synthetic lethality with ruvB, recG, and recQ.
    Title: The rarA gene as part of an expanded RecFOR recombination pathway: Negative epistasis and synthetic lethality with ruvB, recG, and recQ.
  2. RecA-independent recombination: Dependence on the Escherichia coli RarA protein.
    Title: RecA-independent recombination: Dependence on the Escherichia coli RarA protein.
  3. At double-stranded DNA ends, RarA can couple the energy of ATP binding and hydrolysis to separating the strands of duplex DNA, creating flaps
    Title: DNA flap creation by the RarA/MgsA protein of Escherichia coli.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA recombination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA synthesis involved in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA-templated DNA replication IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within protein homotetramerization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of replisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
replication-associated recombination protein A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    937994..939337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415412.1 replication-associated recombination protein A [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415412.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6C9Q7E9, A0A8T5YB88, A0AAN5H3T0
    Conserved Domains (1) summary
    PRK13342
    Location:15 → 439
    PRK13342; recombination factor protein RarA; Reviewed
Nucleotide Protein
Heading Accession and Version

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