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dinG ATP-dependent DNA helicase DinG [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945431, updated on 10-Oct-2024

Summary

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Official Symbol
dinG
Official Full Name
ATP-dependent DNA helicase DinG
Primary source
ECOCYC:EG11357
Locus tag
b0799
See related
ASAP:ABE-0002732
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0788; rarB
Summary
dinG is a non-essential gene. [More information is available at EcoGene: EG11357]. DinG exhibits ATP-dependent DNA helicase activity that may play a role in DNA repair and replication . [More information is available at EcoCyc: EG11357].
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Genomic context

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Sequence:
NC_000913.3 (833070..835220)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ATP-dependent RNA helicase RhlE Neighboring gene N-glycosidase YbiA Neighboring gene nonspecific DNA-binding protein YbiB Neighboring gene hydroxycarboxylate dehydrogenase B Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DNA translocation mechanism of an XPD family helicase. Cheng K, et al. Elife, 2018 Dec 6. PMID 30520735, Free PMC Article
  2. DNA-mediated signaling by proteins with 4Fe-4S clusters is necessary for genomic integrity. Grodick MA, et al. J Am Chem Soc, 2014 Apr 30. PMID 24738733, Free PMC Article
  3. Redox control of the DNA damage-inducible protein DinG helicase activity via its iron-sulfur cluster. Ren B, et al. J Biol Chem, 2009 Feb 20. PMID 19074432, Free PMC Article
  4. The DinG protein from Escherichia coli is a structure-specific helicase. Voloshin ON, et al. J Biol Chem, 2007 Jun 22. PMID 17416902
  5. Interaction of LexA repressor with the asymmetric dinG operator and complete nucleotide sequence of the gene. Lewis LK, et al. J Bacteriol, 1992 Aug. PMID 1629168, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rep and UvrD helicases operate on DNA at the replication fork whereas DinG helicase acts via a different mechanism
    Title: Direct removal of RNA polymerase barriers to replication by accessory replicative helicases.
  2. Here we present crystal structures of complexes of DinG bound to single-stranded DNA (ssDNA) in the presence and absence of an ATP analogue (ADP*BeF3), that suggest a mechanism for 5'-3' translocation along the ssDNA substrate. This proposed mechanism has implications for how those enzymes of the XPD family that recognise bulky DNA lesions might stall at these as the first step in initiating DNA repair
    Title: DNA translocation mechanism of an XPD family helicase.
  3. YbiB from Escherichia coli, the defining member of the novel Trpd2 family of prokaryotic DNA-binding proteins, forms an operon with the DNA helicase gene dinG and is under LexA control.
    Title: YbiB from Escherichia coli, the Defining Member of the Novel TrpD2 Family of Prokaryotic DNA-binding Proteins.
  4. The DNA helicases UvrD and DinG suppress the lethality caused by mutant cspA.
    Title: Identification of two DNA helicases UvrD and DinG as suppressors for lethality caused by mutant cspA mRNAs.
  5. when rRNA operons (rrn) are inverted to face replication, the viability of the dinG mutant is affected and over-expression of RNase H rescues the growth defect, showing that DinG acts in vivo to remove R-loops
    Title: The helicases DinG, Rep and UvrD cooperate to promote replication across transcription units in vivo.
  6. DinG protein from Escherichia coli is a structure-specific helicase involved in recombinational DNA repair and the resumption of replication after DNA damage
    Title: The DinG protein from Escherichia coli is a structure-specific helicase.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 4 iron, 4 sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 5'-3' DNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5'-3' DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA/RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA/RNA helicase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA duplex unwinding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA duplex unwinding IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within DNA repair EXP
Inferred from Experiment
more info
 PubMed 
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in G-quadruplex DNA unwinding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in SOS response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within SOS response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ATP-dependent DNA helicase DinG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    833070..835220
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415320.1 ATP-dependent DNA helicase DinG [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415320.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAN5F9J0, C3THT0
    Conserved Domains (1) summary
    PRK11747
    Location:2 → 696
    dinG; ATP-dependent DNA helicase DinG; Provisional
Nucleotide Protein
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