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recR recombination mediator protein RecR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945100, updated on 19-Sep-2024

Summary

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Official Symbol
recR
Official Full Name
recombination mediator protein RecR
Primary source
ECOCYC:EG10834
Locus tag
b0472
See related
ASAP:ABE-0001638
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0466
Summary
[More information is available at EcoCyc: EG10834].
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Genomic context

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Sequence:
NC_000913.3 (494405..495010)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene adenine phosphoribosyltransferase Neighboring gene DNA polymerase III subunit gamma;DNA polymerase III subunit tau Neighboring gene putative nucleoid-associated protein YbaB Neighboring gene chaperone protein HtpG Neighboring gene adenylate kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of the recR locus of Escherichia coli K-12 and analysis of its role in recombination and DNA repair. Mahdi AA, et al. Mol Gen Genet, 1989 Apr. PMID 2664459
  2. RecF protein targeting to postreplication (daughter strand) gaps I: DNA binding by RecF and RecFR. Henry C, et al. Nucleic Acids Res, 2023 Jun 23. PMID 37125642, Free PMC Article
  3. Sequence and expression of the Escherichia coli recR locus. Yeung T, et al. J Bacteriol, 1990 Oct. PMID 1698765, Free PMC Article
  4. The recR locus of Escherichia coli K-12: molecular cloning, DNA sequencing and identification of the gene product. Mahdi AA, et al. Nucleic Acids Res, 1989 Sep 12. PMID 2674903, Free PMC Article
  5. An interaction between the Escherichia coli RecF and RecR proteins dependent on ATP and double-stranded DNA. Webb BL, et al. J Biol Chem, 1995 Dec 29. PMID 8537414

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RecF protein targeting to postreplication (daughter strand) gaps I: DNA binding by RecF and RecFR.
    Title: RecF protein targeting to postreplication (daughter strand) gaps I: DNA binding by RecF and RecFR.
  2. Allosteric effects of SSB C-terminal tail on assembly of E. coli RecOR proteins.
    Title: Allosteric effects of SSB C-terminal tail on assembly of E. coli RecOR proteins.
  3. RecF foci frequently colocalize with replisome markers. In response to DNA damage, colocalization increases and RecF dimerizes. The majority of RecF foci are dependent on RecR. Conversely, RecO foci occur infrequently, rarely colocalize with replisomes or RecF and are largely independent of RecR.
    Title: RecFOR epistasis group: RecF and RecO have distinct localizations and functions in Escherichia coli.
  4. RecOR, and possibly other SSB-interacting proteins, function(s) in part to alter long-range, macroscopic interactions between or throughout nucleoprotein complexes by microscopically altering wrapping and bridging distant sites.
    Title: Imaging and energetics of single SSB-ssDNA molecules reveal intramolecular condensation and insight into RecOR function.
  5. Data show that UvrD and UvrD252 counteract RecQ, RecJ, and RecFOR at forks blocked in the rep mutant of Escherichia coli.
    Title: UvrD and UvrD252 counteract RecQ, RecJ, and RecFOR in a rep mutant of Escherichia coli.
  6. When an SSB variant that lacks the C-terminal 8 amino acids is used, the capacity of RecOR to facilitate RecA loading onto the ssDNA is largely abolished
    Title: SSB protein limits RecOR binding onto single-stranded DNA.
  7. All three recombination mediator proteins RecFOR are needed to build a functionally competent RecA filament that supports efficient Pol V-mediated translesion synthesis in the presence of ssDNA-binding protein.
    Title: RecFOR proteins are essential for Pol V-mediated translesion synthesis and mutagenesis.
  8. genetic analysis of recombination in a recB recD double mutant was performed; results show that conjugational recombination and DNA repair in this mutant are highly dependent on recJ, partially dependent on recFOR, and independent of recQ
    Title: Effects of recJ, recQ, and recFOR mutations on recombination in nuclease-deficient recB recD double mutants of Escherichia coli.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA recombination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA synthesis involved in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in recombinational repair EXP
Inferred from Experiment
more info
 PubMed 
involved_in recombinational repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to UV EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within response to UV IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
recombination mediator protein RecR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    494405..495010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415005.1 recombination mediator protein RecR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415005.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7D7PGL0
    Conserved Domains (1) summary
    PRK00076
    Location:2 → 199
    recR; recombination protein RecR; Reviewed
Nucleotide Protein
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