U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

htpG chaperone protein HtpG [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945099, updated on 19-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
htpG
Official Full Name
chaperone protein HtpG
Primary source
ECOCYC:EG10461
Locus tag
b0473
See related
ASAP:ABE-0001642
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0467
Summary
HtpG undergoes substantial nucleotide-dependent conformational rearrangements (Huai, 2005; Shiau, 2006). [More information is available at EcoGene: EG10461]. The HtpG protein is the Escherichia coli homolog of the ubiquitous HSP90 family of proteins . [More information is available at EcoCyc: EG10461].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (495120..496994)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA polymerase III subunit gamma;DNA polymerase III subunit tau Neighboring gene putative nucleoid-associated protein YbaB Neighboring gene recombination mediator protein RecR Neighboring gene adenylate kinase Neighboring gene ferrochelatase Neighboring gene acetylesterase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Towards a complete structure of Hsp90. Bracher A, et al. Structure, 2005 Apr. PMID 15837187
  2. Heat shock gene expression in continuous cultures of Escherichia coli. Heitzer A, et al. J Biotechnol, 1992 Jan. PMID 1367813
  3. Some effects of growth conditions on steady state and heat shock induced htpG gene expression in continuous cultures of Escherichia coli. Heitzer A, et al. Arch Microbiol, 1990. PMID 2078102
  4. Acid shock proteins of Escherichia coli. Heyde M, et al. FEMS Microbiol Lett, 1990 May. PMID 2199304
  5. Purification and properties of the Escherichia coli heat shock protein, HtpG. Spence J, et al. J Biol Chem, 1989 Mar 15. PMID 2647735

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Folding and domain interactions of three orthologs of Hsp90 have been reported.
    Title: Folding and Domain Interactions of Three Orthologs of Hsp90 Studied by Single-Molecule Force Spectroscopy.
  2. bacterial Hsp90 (HtpG) has a pH-dependent ATPase activity that is unique among other Hsp90 homologs. The underlying mechanism is a conformation-specific electrostatic interaction between a single histidine, H255, and bound ATP.
    Title: Molecular mechanism of bacterial Hsp90 pH-dependent ATPase activity.
  3. Taken together, these results suggest that a specific region in the nucleotide-binding domain of DnaK is involved in the interaction with Escherichia coli Hsp90, and this interaction is functionally important.
    Title: Interaction of E. coli Hsp90 with DnaK Involves the DnaJ Binding Region of DnaK.
  4. This is the first report highlighting the role of heat shock protein Hps90Ec in the production of two secondary metabolites, colibactin and yersiniabactin, involved in Escherichia coli virulence.
    Title: The Bacterial Stress-Responsive Hsp90 Chaperone (HtpG) Is Required for the Production of the Genotoxin Colibactin and the Siderophore Yersiniabactin in Escherichia coli.
  5. N-terminus verified by Edman degradation on complete protein
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
  6. ADP binding drives dramatic conformational changes, suggesting a mechanism by which nucleotides could control client protein binding and release.
    Title: Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein folding chaperone IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within FtsZ-dependent cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein folding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to heat IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to heat IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
chaperone protein HtpG
NP_415006.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    495120..496994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415006.1 chaperone protein HtpG [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415006.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A895NW17, A0A8T6Q506
    Conserved Domains (1) summary
    PRK05218
    Location:4 → 623
    PRK05218; heat shock protein 90; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.