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murF D-alanyl-D-alanine-adding enzyme [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944813, updated on 2-May-2024

Summary

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Gene symbol
murF
Gene description
D-alanyl-D-alanine-adding enzyme
Primary source
ASAP:ABE-0000313
Locus tag
b0086
See related
ECOCYC:EG10622
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0087; mra
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Genomic context

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Sequence:
NC_000913.3 (94650..96008)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene 16S rRNA m(4)C1402 methyltransferase Neighboring gene cell division protein FtsL Neighboring gene peptidoglycan DD-transpeptidase FtsI Neighboring gene ncRNA Neighboring gene UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase Neighboring gene phospho-N-acetylmuramoyl-pentapeptide-transferase Neighboring gene UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase Neighboring gene peptidoglycan glycosyltransferase FtsW Neighboring gene N-acetylglucosaminyl transferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MurF inhibitors with antibacterial activity: effect on muropeptide levels. Baum EZ, et al. Antimicrob Agents Chemother, 2009 Aug. PMID 19470511, Free PMC Article
  2. A MurF inhibitor that disrupts cell wall biosynthesis in Escherichia coli. Baum EZ, et al. Antimicrob Agents Chemother, 2007 Dec. PMID 17908943, Free PMC Article
  3. Utility of muropeptide ligase for identification of inhibitors of the cell wall biosynthesis enzyme MurF. Baum EZ, et al. Antimicrob Agents Chemother, 2006 Jan. PMID 16377691, Free PMC Article
  4. Crystal structure of Escherichia coli UDPMurNAc-tripeptide d-alanyl-d-alanine-adding enzyme (MurF) at 2.3 A resolution. Yan Y, et al. J Mol Biol, 2000 Dec 1. PMID 11090285
  5. Crystallization and preliminary X-ray analysis of the Escherichia coli UDP-MurNAc-tripeptide D-alanyl-D-alanine-adding enzyme (MurF). Yan Y, et al. Acta Crystallogr D Biol Crystallogr, 1999 Dec. PMID 10666581

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Purification and characterization of the D-alanyl-D-alanine-adding enzyme from Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables acid-amino acid ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptidoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
D-alanyl-D-alanine-adding enzyme
NP_414628.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    94650..96008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414628.1 D-alanyl-D-alanine-adding enzyme [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414628.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A776LN25, A0A8T6BIA4, A0A8T6PMM5
    Conserved Domains (1) summary
    PRK10773
    Location:1 → 452
    murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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