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NCR2 natural cytotoxicity triggering receptor 2 [ Homo sapiens (human) ]

Gene ID: 9436, updated on 2-Nov-2024

Summary

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Official Symbol
NCR2provided by HGNC
Official Full Name
natural cytotoxicity triggering receptor 2provided by HGNC
Primary source
HGNC:HGNC:6732
See related
Ensembl:ENSG00000096264 MIM:604531; AllianceGenome:HGNC:6732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LY95; CD336; NKP44; NK-p44; dJ149M18.1
Summary
Predicted to enable signaling receptor activity. Predicted to be involved in cellular defense response and signal transduction. Predicted to be located in plasma membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
all
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Genomic context

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See NCR2 in Genome Data Viewer
Location:
6p21.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (41335608..41350889)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (41164903..41180184)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41303346..41318627)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr6:41272623-41273180 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:41273648-41274847 Neighboring gene RNA, U6 small nuclear 643, pseudogene Neighboring gene ribosomal protein L32 pseudogene 15 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:41286938-41287479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24505 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17177 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:41337197-41337697 Neighboring gene MPRA-validated peak5801 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:41338977-41339930 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:41341839-41342790 Neighboring gene uncharacterized LOC100505711 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:41374298-41375106 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:41375914-41376721 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:41376722-41377528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24507 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17178 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17179 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:41396875-41397374 Neighboring gene uncharacterized LOC107986538

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. H5-type influenza virus hemagglutinin is functionally recognized by the natural killer-activating receptor NKp44. Ho JW, et al. J Virol, 2008 Feb. PMID 18077718, Free PMC Article
  2. NKp44/HLA-DP-dependent regulation of CD8 effector T cells by NK cells. Padoan B, et al. Cell Rep, 2024 Apr 23. PMID 38615318, Free PMC Article
  3. RORγt⁺ innate lymphoid cells acquire a proinflammatory program upon engagement of the activating receptor NKp44. Glatzer T, et al. Immunity, 2013 Jun 27. PMID 23791642
  4. Natural killer cells in HIV controller patients express an activated effector phenotype and do not up-regulate NKp44 on IL-2 stimulation. Marras F, et al. Proc Natl Acad Sci U S A, 2013 Jul 16. PMID 23818644, Free PMC Article
  5. NKp44 receptor mediates interaction of the envelope glycoproteins from the West Nile and dengue viruses with NK cells. Hershkovitz O, et al. J Immunol, 2009 Aug 15. PMID 19635919, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NKp44/HLA-DP-dependent regulation of CD8 effector T cells by NK cells.
    Title: NKp44/HLA-DP-dependent regulation of CD8 effector T cells by NK cells.
  2. Human NKp44(+) Group 3 Innate Lymphoid Cells Associate with Tumor-Associated Tertiary Lymphoid Structures in Colorectal Cancer.
    Title: Human NKp44(+) Group 3 Innate Lymphoid Cells Associate with Tumor-Associated Tertiary Lymphoid Structures in Colorectal Cancer.
  3. Low-dose IL-2 induces CD56(bright) NK regulation of T cells via NKp44 and NKp46.
    Title: Low-dose IL-2 induces CD56(bright) NK regulation of T cells via NKp44 and NKp46.
  4. The Natural Cytotoxicity Receptors in Health and Disease.
    Title: The Natural Cytotoxicity Receptors in Health and Disease.
  5. NKp44-NKp44 Ligand Interactions in the Regulation of Natural Killer Cells and Other Innate Lymphoid Cells in Humans.
    Title: NKp44-NKp44 Ligand Interactions in the Regulation of Natural Killer Cells and Other Innate Lymphoid Cells in Humans.
  6. We therefore identified the NKp44 binding site to PCNA and further developed an NKp44-peptide-based agent that can inhibit tumor growth through interfering with the function of intracellular PCNA in the tumor cell.
    Title: NKp44-Derived Peptide Binds Proliferating Cell Nuclear Antigen and Mediates Tumor Cell Death.
  7. Increased expression of p44 natural killer cell receptor (NKp44 ) was associated earlier stages of diffuse large B-cell lymphoma (DLBCL).
    Title: Modulation the expression of natural killer cell activating receptor (NKp44) in the peripheral blood of diffuse large B-cell lymphoma patients and the correlation with clinic pathological features.
  8. The regulation of T cell proliferation during HPIV3 infection is mediated via NK receptors NKp44 and NKp46 and involves the surface glycoprotein haemagglutinin-neuraminidase but not the fusion protein of the virus.
    Title: Haemagglutinin-neuraminidase from HPIV3 mediates human NK regulation of T cell proliferation via NKp44 and NKp46.
  9. Study identified a novel ligand for NKp44 on astrocytes. Expression of this novel ligand decreased with increasing HIV-3S peptide concentration and blocking this novel ligand decreased NK cell killing. NK cell killing of astrocytes was decreased when astrocytes were incubated with HIV-3S peptide. NKp44 has a protective effect on astrocytes from NK cell mediated killing during HIV infection and impact astrocyte's role.
    Title: A novel ligand on astrocytes interacts with natural cytotoxicity receptor NKp44 regulating immune response mediated by NK cells.
  10. NKp44 and NKp30 splice variants profiles are tissue/condition specific and demonstrate similarity between placenta and cancerous tissues.
    Title: NKp44 and NKp30 splice variant profiles in decidua and tumor tissues: a comparative viewpoint.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Exploring the genetic basis of chronic periodontitis: a genome-wide association study.
EBI GWAS Catalog
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
EBI GWAS Catalog
GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular defense response TAS
Traceable Author Statement
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
natural cytotoxicity triggering receptor 2
Names
NK cell activating receptor (NKp44)
NK cell-activating receptor
lymphocyte antigen 95 (activating NK-receptor; NK-p44)
lymphocyte antigen 95 homolog (activating NK-receptor; NK-p44)
natural killer cell p44-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199509.2 → NP_001186438.1  natural cytotoxicity triggering receptor 2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an additional in-frame segment and an additional exon which results in frame-shift, as compared to variant 1. The resulting isoform (2) has an additional internal segment and a shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AL136967
    Consensus CDS
    CCDS56428.1
    UniProtKB/Swiss-Prot
    O95944
    Related
    ENSP00000362178.3, ENST00000373086.3
    Conserved Domains (2) summary
    cd05716
    Location:27 → 124
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:31 → 129
    IG_like; Immunoglobulin like

  2. NM_001199510.2 → NP_001186439.1  natural cytotoxicity triggering receptor 2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001186439.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an additional exon which results in frame-shift, as compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AL136967
    Consensus CDS
    CCDS56429.1
    UniProtKB/Swiss-Prot
    O95944
    Related
    ENSP00000362175.4, ENST00000373083.8
    Conserved Domains (2) summary
    cd05716
    Location:27 → 124
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:31 → 129
    IG_like; Immunoglobulin like

  3. NM_004828.4 → NP_004819.2  natural cytotoxicity triggering receptor 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_004819.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL136967
    Consensus CDS
    CCDS4855.1
    UniProtKB/Swiss-Prot
    O95944, Q9H562, Q9H563, Q9H564, Q9UMT1, Q9UMT2
    Related
    ENSP00000362181.5, ENST00000373089.10
    Conserved Domains (3) summary
    cd05716
    Location:27 → 124
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    PHA03282
    Location:93 → 175
    PHA03282; envelope glycoprotein E; Provisional
    smart00410
    Location:31 → 129
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    41335608..41350889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011500.2 → XP_016866989.1  natural cytotoxicity triggering receptor 2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    41164903..41180184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356827.1 → XP_054212802.1  natural cytotoxicity triggering receptor 2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O95944.2 GenPept UniProtKB/Swiss-Prot:O95944

Gene LinkOut

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