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Psmb1 proteasome 20S subunit beta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 94198, updated on 2-Nov-2024

Summary

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Official Symbol
Psmb1provided by RGD
Official Full Name
proteasome 20S subunit beta 1provided by RGD
Primary source
RGD:621092
See related
EnsemblRapid:ENSRNOG00000001488 AllianceGenome:RGD:621092
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be located in nucleoplasm. Predicted to be part of proteasome core complex, beta-subunit complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human PSMB1 (proteasome 20S subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 881.9), Heart (RPKM 866.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Psmb1 in Genome Data Viewer
Location:
1q12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (65115770..65136516, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (56442432..56463544, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (57470878..57491359, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 120 member B Neighboring gene delta like canonical Notch ligand 1 Neighboring gene uncharacterized LOC102557016 Neighboring gene TATA box binding protein Neighboring gene programmed cell death 2 Neighboring gene BRCA1 associated RING domain 1, pseudogene 1 Neighboring gene PR/SET domain 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. cDNA cloning and sequencing of component C5 of proteasomes from rat hepatoma cells. Tamura T, et al. FEBS Lett, 1990 May 7. PMID 2338147
  2. The NH2-terminal residues of rat liver proteasome (multicatalytic proteinase complex) subunits, C2, C3 and C8, are N alpha-acetylated. Tokunaga F, et al. FEBS Lett, 1990 Apr 24. PMID 2335242
  3. A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1. Moscovitz O, et al. Mol Cell, 2012 Jul 13. PMID 22793692
  4. Regulation of CD8+ T cell development by thymus-specific proteasomes. Murata S, et al. Science, 2007 Jun 1. PMID 17540904
  5. PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasis. Sasaki K, et al. Mol Cell Biol, 2010 Aug. PMID 20498273, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome core complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex ISO
Inferred from Sequence Orthology
more info
  
part_of proteasome core complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of proteasome core complex, beta-subunit complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
proteasome subunit beta type-1
Names
beta-6
macropain subunit C5
multicatalytic endopeptidase complex subunit C5
proteasome (prosome, macropain) subunit, beta type 1
proteasome beta 1 subunit
proteasome component C5
proteasome gamma chain
proteasome subunit RC5
proteasome subunit beta 1
proteasome subunit beta-6
NP_446042.1
XP_038949069.1
XP_038949071.1
XP_063132072.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053590.1 → NP_446042.1  proteasome subunit beta type-1 precursor

    See identical proteins and their annotated locations for NP_446042.1

    Status: PROVISIONAL

    Source sequence(s)
    X52783
    UniProtKB/Swiss-Prot
    P18421
    Conserved Domains (1) summary
    cd03757
    Location:29 → 240
    proteasome_beta_type_1; proteasome beta type-1 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    65115770..65136516 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093141.2 → XP_038949069.1  proteasome subunit beta type-1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZZZ8
    Related
    ENSRNOP00000085774.1, ENSRNOT00000093808.2
    Conserved Domains (1) summary
    cd03757
    Location:21 → 223
    proteasome_beta_type_1; proteasome beta type-1 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

  2. XM_063276002.1 → XP_063132072.1  proteasome subunit beta type-1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y6U8, Q6PDW4

  3. XM_039093143.2 → XP_038949071.1  proteasome subunit beta type-1 isoform X3

    UniProtKB/TrEMBL
    A6KB45
    Conserved Domains (1) summary
    cl00467
    Location:1 → 140
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18421.3 GenPept UniProtKB/Swiss-Prot:P18421

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