U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NMT2 N-myristoyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 9397, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
NMT2provided by HGNC
Official Full Name
N-myristoyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:7858
See related
Ensembl:ENSG00000152465 MIM:603801; AllianceGenome:HGNC:7858
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes one of two N-myristoyltransferase proteins. N-terminal myristoylation is a lipid modification that is involved in regulating the function and localization of signaling proteins. The encoded protein catalyzes the addition of a myristoyl group to the N-terminal glycine residue of many signaling proteins, including the human immunodeficiency virus type 1 (HIV-1) proteins, Gag and Nef. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Ubiquitous expression in fat (RPKM 9.3), testis (RPKM 5.5) and 24 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See NMT2 in Genome Data Viewer
Location:
10p13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (15105700..15168693, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (15119744..15183186, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (15147769..15210692, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:15138899-15139470 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3091 Neighboring gene RPP38 divergent transcript Neighboring gene ribonuclease P/MRP subunit p38 Neighboring gene uncharacterized LOC105376431 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3092 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3093 Neighboring gene uncharacterized LOC107984210 Neighboring gene peptidylprolyl isomerase A pseudogene 30 Neighboring gene MPRA-validated peak871 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2169 Neighboring gene cytochrome c oxidase subunit NDUFA4-like Neighboring gene uncharacterized LOC105376434 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:15242369-15243568

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-mytistoyltransferase 1 and 2 are potential tumor suppressors and novel targets of miR-182 in human non-small cell lung carcinomas.
    Title: N-mytistoyltransferase 1 and 2 are potential tumor suppressors and novel targets of miR-182 in human non-small cell lung carcinomas.
  2. ligand binding properties of the NMT/ACBD6 complex can explain how the NMT reaction can proceed in the presence of the very abundant competitive substrate, C(16)-CoA.
    Title: Association of NMT2 with the acyl-CoA carrier ACBD6 protects the N-myristoyltransferase reaction from palmitoyl-CoA.
  3. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  6. Nef is preferentially myristoylated by NMT2, suggesting that selective inhibition of NMT2 may provide a novel means of blocking HIV virulence.
    Title: N-Myristoyltransferase isozymes exhibit differential specificity for human immunodeficiency virus type 1 Gag and Nef.
  7. Disruption of the gene for NMT2 by a t(8;10) translocation in a male with hypogonadism.
    Title: Is the disruption of an N-myristoyltransferase (NMT2) associated with hypoplastic testes?
  8. Protein-protein interaction of NMTs revealed that m-calpain interacts with NMT1 while caspase-3 interacts with NMT2.
    Title: N-myristoyltransferase 2 expression in human colon cancer: cross-talk between the calpain and caspase system.
  9. Involved in progression and regulation of telomerase
    Title: Genes associated with telomerase activity levels in esophageal carcinoma cell lines.
  10. induction of NMT2 may play a central role in dioxin carcinogenicity.
    Title: Novel target genes of the Ah (dioxin) receptor: transcriptional induction of N-myristoyltransferase 2.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Nef nef The N-terminal methionine of HIV-1 Nef is myristoylated by N-myristoyltransferase PubMed
matrix gag HIV-1 Matrix is myristoylated on its N-terminal glycine residue by N-myristoyltransferase, a chemical modification important for membrane targeting of Gag/Matrix, for facilitating Matrix multimerization, and for virus particle formation and budding PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables glycylpeptide N-tetradecanoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycylpeptide N-tetradecanoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycylpeptide N-tetradecanoyltransferase activity TAS
Traceable Author Statement
more info
  
enables peptidyl-lysine N6-myristoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-terminal peptidyl-glycine N-myristoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular transport of virus TAS
Traceable Author Statement
more info
  
involved_in protein localization to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of opsin-mediated signaling pathway TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in host cell IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
glycylpeptide N-tetradecanoyltransferase 2
Names
NMT 2
myristoyl-CoA:protein N-myristoyltransferase 2
peptide N-myristoyltransferase 2
protein-lysine myristoyltransferase NMT2
type II N-myristoyltransferase
NP_001295224.1
NP_004799.1
XP_005252699.1
XP_006717602.1
XP_016872438.1
XP_016872440.1
XP_024304030.1
XP_047281975.1
XP_054223165.1
XP_054223166.1
XP_054223167.1
XP_054223168.1
XP_054223169.1
XP_054223170.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308295.2 → NP_001295224.1  glycylpeptide N-tetradecanoyltransferase 2 isoform 2

    See identical proteins and their annotated locations for NP_001295224.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate exon which results in the use of an alternate start codon and a frameshifted 5' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AF043325, AF086423, AK094904, AL590365, DB465189
    Consensus CDS
    CCDS76284.1
    UniProtKB/TrEMBL
    B3KT39, Q5VUC6
    Related
    ENSP00000367392.1, ENST00000378150.1
    Conserved Domains (1) summary
    cl27359
    Location:106 → 473
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

  2. NM_004808.3 → NP_004799.1  glycylpeptide N-tetradecanoyltransferase 2 isoform 1

    See identical proteins and their annotated locations for NP_004799.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF043325, AL590365
    Consensus CDS
    CCDS7109.1
    UniProtKB/Swiss-Prot
    B0YJ49, O60551, Q53Y38, Q5VUC8, Q9BRB4
    UniProtKB/TrEMBL
    B2RCF3
    Related
    ENSP00000367407.3, ENST00000378165.9
    Conserved Domains (1) summary
    cl27359
    Location:119 → 486
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    15105700..15168693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426019.1 → XP_047281975.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X4

  2. XM_005252642.6 → XP_005252699.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X1

    UniProtKB/TrEMBL
    B2RCF3
    Conserved Domains (2) summary
    pfam01233
    Location:140 → 294
    NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
    pfam02799
    Location:310 → 485
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

  3. XM_017016949.3 → XP_016872438.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X2

    UniProtKB/TrEMBL
    B3KT39

  4. XM_006717539.5 → XP_006717602.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X3

    UniProtKB/TrEMBL
    B2RCF3
    Conserved Domains (2) summary
    pfam01233
    Location:140 → 256
    NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
    pfam02799
    Location:253 → 428
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

  5. XM_017016951.3 → XP_016872440.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X5

    UniProtKB/TrEMBL
    B3KT39

  6. XM_024448262.2 → XP_024304030.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X6

    UniProtKB/TrEMBL
    B3KT39, B4DHU9
    Conserved Domains (1) summary
    cl27359
    Location:32 → 399
    NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    15119744..15183186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367192.1 → XP_054223167.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X3

  2. XM_054367194.1 → XP_054223169.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X5

  3. XM_054367195.1 → XP_054223170.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X6

  4. XM_054367193.1 → XP_054223168.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X4

  5. XM_054367190.1 → XP_054223165.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X1

  6. XM_054367191.1 → XP_054223166.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O60551.1 GenPept UniProtKB/Swiss-Prot:O60551

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous