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splB spore photoproduct (thymine dimer) lyase [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 939248, updated on 12-Feb-2021

Summary

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Gene symbol
splB
Gene description
spore photoproduct (thymine dimer) lyase
Locus tag
BSU_13930
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU13930
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Genomic context

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Sequence:
NC_000964.3 (1461770..1462798)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) (HPr protein) Neighboring gene phosphotransferase system (PTS) enzyme I Neighboring gene TRAP-like transcriptional negative regulator of spore photoproduct lyase Neighboring gene putative acetyltransferase / amidohydrolase Neighboring gene methyl-accepting chemotaxis protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Spore photoproduct within DNA is a surprisingly poor substrate for its designated repair enzyme-The spore photoproduct lyase. Yang L, et al. DNA Repair (Amst), 2017 May. PMID 28320593, Free PMC Article
  2. The structure of an authentic spore photoproduct lesion in DNA suggests a basis for recognition. Singh I, et al. Acta Crystallogr D Biol Crystallogr, 2014 Mar. PMID 24598744, Free PMC Article
  3. DNA repair and free radicals, new insights into the mechanism of spore photoproduct lyase revealed by single amino acid substitution. Chandor-Proust A, et al. J Biol Chem, 2008 Dec 26. PMID 18957420, Free PMC Article
  4. Dinucleotide spore photoproduct, a minimal substrate of the DNA repair spore photoproduct lyase enzyme from Bacillus subtilis. Chandor A, et al. J Biol Chem, 2006 Sep 15. PMID 16829676
  5. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SPL represents an unprecedented example of a major DNA repair enzyme that cannot effectively repair its substrate lesion within the normal DNA conformation adopted in growing cells. Factors such as other DNA binding proteins, helicases or an altered DNA conformation may cooperate with SPL to enable efficient SP repair in germinating spores.
    Title: Spore photoproduct within DNA is a surprisingly poor substrate for its designated repair enzyme-The spore photoproduct lyase.
  2. Unusual structural features associated with B. subtilis spore photoproduct (SP) lesions may provide a basis for recognition by SP lyase.
    Title: The structure of an authentic spore photoproduct lesion in DNA suggests a basis for recognition.
  3. analysis of the mechanism of spore photoproduct lyase revealed by single amino acid substitution
    Title: DNA repair and free radicals, new insights into the mechanism of spore photoproduct lyase revealed by single amino acid substitution.
  4. Dinucleotide spore photoproduct is a minimal substrate of the DNA repair spore photoproduct lyase enzyme from Bacillus subtilis
    Title: Dinucleotide spore photoproduct, a minimal substrate of the DNA repair spore photoproduct lyase enzyme from Bacillus subtilis.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
spore photoproduct (thymine dimer) lyase
NP_389276.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411; Product type e: enzyme

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_389276.1 spore photoproduct (thymine dimer) lyase [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_389276.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P37956
    Conserved Domains (1) summary
    TIGR04070
    Location:5 → 342
    photo_TT_lyase; spore photoproduct lyase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37956.1

Gene LinkOut

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