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perR transcriptional regulator (Fur family) [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 939227, updated on 12-Feb-2021

Summary

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Gene symbol
perR
Gene description
transcriptional regulator (Fur family)
Locus tag
BSU_08730
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU08730
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Genomic context

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Sequence:
NC_000964.3 (944487..944924)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene glutamate-1-semialdehyde aminotransferase, class III aminotransferase Neighboring gene peroxiredoxin with versatile activity Neighboring gene hypothetical protein Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Oxidization without substrate unfolding triggers proteolysis of the peroxide-sensor, PerR. Ahn BE, et al. Proc Natl Acad Sci U S A, 2016 Jan 5. PMID 26677871, Free PMC Article
  2. Structural characterization of the active form of PerR: insights into the metal-induced activation of PerR and Fur proteins for DNA binding. Jacquamet L, et al. Mol Microbiol, 2009 Jul. PMID 19508285
  3. Biochemical characterization of the structural Zn2+ site in the Bacillus subtilis peroxide sensor PerR. Lee JW, et al. J Biol Chem, 2006 Aug 18. PMID 16766519
  4. The H2O2 stress-responsive regulator PerR positively regulates srfA expression in Bacillus subtilis. Hayashi K, et al. J Bacteriol, 2005 Oct. PMID 16166527, Free PMC Article
  5. Intracellular Zn(II) Intoxication Leads to Dysregulation of the PerR Regulon Resulting in Heme Toxicity in Bacillus subtilis. Chandrangsu P, et al. PLoS Genet, 2016 Dec. PMID 27935957, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bacillus subtilis Fur Is a Transcriptional Activator for the PerR-Repressed pfeT Gene, Encoding an Iron Efflux Pump.
    Title: Bacillus subtilis Fur Is a Transcriptional Activator for the PerR-Repressed pfeT Gene, Encoding an Iron Efflux Pump.
  2. eme accumulation results from dysregulation of the regulon controlled by PerR, a metal-dependent repressor of peroxide stress genes. When metallated with Fe(II) or Mn(II), PerR represses both heme biosynthesis (hemAXCDBL operon) and the abundant heme protein catalase (katA).
    Title: Intracellular Zn(II) Intoxication Leads to Dysregulation of the PerR Regulon Resulting in Heme Toxicity in Bacillus subtilis.
  3. this study identified a LonA-recognition site critical for oxidation-controlled PerR turnover.
    Title: Oxidization without substrate unfolding triggers proteolysis of the peroxide-sensor, PerR.
  4. Single asparagine to arginine mutation allows PerR to switch from PerR box to Fur box.
    Title: Single asparagine to arginine mutation allows PerR to switch from PerR box to fur box.
  5. Iron and manganese homeostasis in Bacillus subtilis involves three key regulators: Fur senses iron sufficiency, MntR senses manganese sufficiency, and PerR senses the intracellular Fe/Mn ratio. (Review)
    Title: Specificity of metal sensing: iron and manganese homeostasis in Bacillus subtilis.
  6. PerR repression of fur is enhanced by Mn(II), and antagonized by Fe(II), PerR may co-regulate Fe(II) homeostasis by modulating Fur levels in response to the Mn(II)/Fe(II) ratio.
    Title: Origins of specificity and cross-talk in metal ion sensing by Bacillus subtilis Fur.
  7. A specific histidine residue makes the N- and C-terminal domains tadopt a caliper-like conformation suited to bind DNA.
    Title: Structural characterization of the active form of PerR: insights into the metal-induced activation of PerR and Fur proteins for DNA binding.
  8. A model is proposed in which high levels of H2O2 release sufficient ferrous iron (Fe2+) into the cytosol to effect a transition of PerR from the PerR:Zn.Mn form to the peroxide sensititve PerR:Zn.Fe form.
    Title: Biochemical characterization of the structural Zn2+ site in the Bacillus subtilis peroxide sensor PerR.
  9. A transcriptional srfA-lacZ fusion lacking both PerR boxes showed diminished and PerR-independent expression, indicating that the PerR boxes we identified function as positive cis elements for srfA transcription
    Title: The H2O2 stress-responsive regulator PerR positively regulates srfA expression in Bacillus subtilis.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
transcriptional regulator (Fur family)
NP_388753.1
  • Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1580225, 16541078, 16925555, 22194458, 27935957, 22720735; Product type r : regulator

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_388753.1 transcriptional regulator (Fur family) [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_388753.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P71086
    Conserved Domains (1) summary
    COG0735
    Location:4 → 145
    Fur; Fe2+ or Zn2+ uptake regulation protein [Inorganic ion transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P71086.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases