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PestiV2gp1 polyprotein [ Classical swine fever virus ]

Gene ID: 920146, updated on 4-Jan-2024

Summary

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Gene symbol
PestiV2gp1
Gene description
polyprotein
Locus tag
PestiV2gp1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Classical swine fever virus (strain: strain Eystrup)
Lineage
Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage; Flaviviridae; Pestivirus
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Genomic context

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Sequence:
NC_002657.1 (374..12070)

NC_002657.1Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002657.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Classical swine fever virus NS5A protein activates autophagy via the PP2A-DAPK3-Beclin 1 axis.
    Title: Classical swine fever virus NS5A protein activates autophagy via the PP2A-DAPK3-Beclin 1 axis.
  2. The NS4A Protein of Classical Swine Fever Virus Suppresses RNA Silencing in Mammalian Cells.
    Title: The NS4A Protein of Classical Swine Fever Virus Suppresses RNA Silencing in Mammalian Cells.
  3. The Unique Glycosylation at Position 986 on the E2 Glycoprotein of Classical Swine Fever Virus Is Responsible for Viral Attenuation and Protection against Lethal Challenge.
    Title: The Unique Glycosylation at Position 986 on the E2 Glycoprotein of Classical Swine Fever Virus Is Responsible for Viral Attenuation and Protection against Lethal Challenge.
  4. Identification of a Common Conformational Epitope on the Glycoprotein E2 of Classical Swine Fever Virus and Border Disease Virus.
    Title: Identification of a Common Conformational Epitope on the Glycoprotein E2 of Classical Swine Fever Virus and Border Disease Virus.
  5. An induced-fit de novo initiation mechanism suggested by a pestivirus RNA-dependent RNA polymerase.
    Title: An induced-fit de novo initiation mechanism suggested by a pestivirus RNA-dependent RNA polymerase.
  6. Structural Glycoprotein E2 of Classical Swine Fever Virus Critically Interacts with Host Protein Torsin-1A during the Virus Infectious Cycle.
    Title: Structural Glycoprotein E2 of Classical Swine Fever Virus Critically Interacts with Host Protein Torsin-1A during the Virus Infectious Cycle.
  7. Swine Host Protein Coiled-Coil Domain-Containing 115 (CCDC115) Interacts with Classical Swine Fever Virus Structural Glycoprotein E2 during Virus Replication.
    Title: Swine Host Protein Coiled-Coil Domain-Containing 115 (CCDC115) Interacts with Classical Swine Fever Virus Structural Glycoprotein E2 during Virus Replication.
  8. Rab18 binds to classical swine fever virus NS5A and mediates viral replication and assembly in swine umbilical vein endothelial cells.
    Title: Rab18 binds to classical swine fever virus NS5A and mediates viral replication and assembly in swine umbilical vein endothelial cells.
  9. Npro of Classical Swine Fever Virus suppresses Type III interferon production by inhibiting IRF1 expression and Its nuclear translocation
    Title: Npro of Classical Swine Fever Virus Suppresses Type III Interferon Production by Inhibiting IRF1 Expression and Its Nuclear Translocation.
  10. The ability of Classical Swine Fever Virus E2 protein to bind host DCTN6 protein efficiently during infection may play a role in viral virulence.
    Title: Structural Glycoprotein E2 of Classical Swine Fever Virus Interacts with Host Protein Dynactin Subunit 6 (DCTN6) during the Virus Infectious Cycle.
Submit: New GeneRIF Correction See all GeneRIFs (73)

General protein information

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Preferred Names
polyprotein
Names
N-Pro
capsid protein
RNAse
envelope glycoprotein E1
envelope glycoprotein E2
E2*
nonstructural protein p7
NTPase/RNA helicase (NS3)
NTPase/RNA helicase
nonstructural protein NS4A
nonstructural protein NS4B
nonstructural protein NS5A
RNA-dependent RNA polymerase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002657.1 Reference assembly

    Range
    374..12070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_075354.1 polyprotein [Classical swine fever virus]

    See identical proteins and their annotated locations for NP_075354.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E2G847, Q99BK1
    Conserved Domains (9) summary
    cd00046
    Location:1816 → 1942
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cd01699
    Location:3419 → 3707
    RNA_dep_RNAP; RNA_dep_RNAP: RNA-dependent RNA polymerase (RdRp) is an essential protein encoded in the genomes of all RNA containing viruses with no DNA stage. RdRp catalyzes synthesis of the RNA strand complementary to a given RNA template. RdRps of many viruses are ...
    pfam00271
    Location:1984 → 2100
    Helicase_C; Helicase conserved C-terminal domain
    pfam05550
    Location:1 → 168
    Peptidase_C53; Pestivirus Npro endopeptidase C53
    pfam05578
    Location:1590 → 1800
    Peptidase_S31; Pestivirus NS3 polyprotein peptidase S31
    pfam11889
    Location:170 → 217
    DUF3409; Domain of unknown function (DUF3409)
    pfam12387
    Location:1323 → 1522
    Peptidase_C74; Pestivirus NS2 peptidase
    pfam16329
    Location:691 → 1026
    Pestivirus_E2; Pestivirus envelope glycoprotein E2
    cl00208
    Location:289 → 353
    RNase_T2; Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf ...

  2. NP_777494.1 N-Pro

    UniProtKB/TrEMBL
    Q9QJU8
    Conserved Domains (1) summary
    pfam05550
    Location:1 → 168
    Peptidase_C53; Pestivirus Npro endopeptidase C53

  3. NP_777495.1 capsid protein

    Conserved Domains (1) summary
    pfam11889
    Location:2 → 49
    DUF3409; Domain of unknown function (DUF3409)

  4. NP_777496.1 RNAse

    UniProtKB/TrEMBL
    Q068A1, Q068A3, Q068A4, Q068A5
    Conserved Domains (1) summary
    cl00208
    Location:22 → 86
    RNase_T2; Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf ...

  5. NP_777497.1 envelope glycoprotein E1

  6. NP_777498.1 envelope glycoprotein E2

    UniProtKB/TrEMBL
    A0A482F669
    Conserved Domains (1) summary
    pfam16329
    Location:2 → 337
    Pestivirus_E2; Pestivirus envelope glycoprotein E2

  7. NP_777499.1 E2*

    UniProtKB/TrEMBL
    A0A8E4V086
    Conserved Domains (1) summary
    pfam16329
    Location:2 → 337
    Pestivirus_E2; Pestivirus envelope glycoprotein E2

  8. NP_777500.1 nonstructural protein p7

  9. NP_777501.1 NTPase/RNA helicase (NS3)

    Conserved Domains (4) summary
    cd00046
    Location:684 → 810
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00271
    Location:852 → 968
    Helicase_C; Helicase conserved C-terminal domain
    pfam05578
    Location:458 → 668
    Peptidase_S31; Pestivirus NS3 polyprotein peptidase S31
    pfam12387
    Location:191 → 390
    Peptidase_C74; Pestivirus NS2 peptidase

  10. NP_777502.1 NTPase/RNA helicase

    UniProtKB/TrEMBL
    A0A0C5PGC2
    Conserved Domains (3) summary
    cd00046
    Location:227 → 353
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00271
    Location:395 → 511
    Helicase_C; Helicase conserved C-terminal domain
    pfam05578
    Location:1 → 211
    Peptidase_S31; Pestivirus NS3 polyprotein peptidase S31

  11. NP_777503.1 nonstructural protein NS4A

  12. NP_777504.1 nonstructural protein NS4B

  13. NP_777505.1 nonstructural protein NS5A

  14. NP_777506.1 RNA-dependent RNA polymerase

    Conserved Domains (1) summary
    cd01699
    Location:239 → 527
    RNA_dep_RNAP; RNA_dep_RNAP: RNA-dependent RNA polymerase (RdRp) is an essential protein encoded in the genomes of all RNA containing viruses with no DNA stage. RdRp catalyzes synthesis of the RNA strand complementary to a given RNA template. RdRps of many viruses are ...
Protein Accession Links
GenPept Link UniProtKB Link
AAG59829.1

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