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CENPL centromere protein L [ Homo sapiens (human) ]

Gene ID: 91687, updated on 2-Nov-2024

Summary

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Official Symbol
CENPLprovided by HGNC
Official Full Name
centromere protein Lprovided by HGNC
Primary source
HGNC:HGNC:17879
See related
Ensembl:ENSG00000120334 MIM:611503; AllianceGenome:HGNC:17879
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CENP-L; C1orf155; dJ383J4.3
Summary
CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) [PubMed 16622420].[supplied by OMIM, Mar 2008]
Expression
Broad expression in testis (RPKM 4.2), bone marrow (RPKM 2.4) and 22 other tissues See more
Orthologs
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Genomic context

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See CENPL in Genome Data Viewer
Location:
1q25.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (173799550..173824883, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (173157718..173183047, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (173768688..173794021, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene kelch like family member 20 Neighboring gene ribosomal protein S27 pseudogene 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:173728073-173728573 Neighboring gene RN7SK pseudogene 160 Neighboring gene MPRA-validated peak463 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2116 Neighboring gene H3K27ac hESC enhancers GRCh37_chr1:173793515-173794033 and GRCh37_chr1:173794034-173794551 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:173795193-173795706 Neighboring gene aspartyl-tRNA synthetase 2, mitochondrial Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:173821280-173822182 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:173830052-173830768 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:173830769-173831485 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1556 Neighboring gene GAS5 antisense RNA 1 Neighboring gene small nucleolar RNA, C/D box 81 Neighboring gene growth arrest specific 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CENPL accelerates cell proliferation, cell cycle, apoptosis, and glycolysis via the MEK1/2-ERK1/2 pathway in hepatocellular carcinoma. He K, et al. Int J Biochem Cell Biol, 2024 Jan. PMID 37914022
  2. Highly expressed centromere protein L indicates adverse survival and associates with immune infiltration in hepatocellular carcinoma. Zeng Z, et al. Aging (Albany NY), 2021 Oct 4. PMID 34607313, Free PMC Article
  3. High mRNA Expression of CENPL and Its Significance in Prognosis of Hepatocellular Carcinoma Patients. Cui Z, et al. Dis Markers, 2021. PMID 34457090, Free PMC Article
  4. Overexpression of CENPL mRNA potentially regulated by miR-340-3p predicts the prognosis of pancreatic cancer patients. Cui Z, et al. BMC Cancer, 2022 Dec 26. PMID 36572856, Free PMC Article
  5. The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface. McKinley KL, et al. Mol Cell, 2015 Dec 17. PMID 26698661, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CENPL accelerates cell proliferation, cell cycle, apoptosis, and glycolysis via the MEK1/2-ERK1/2 pathway in hepatocellular carcinoma.
    Title: CENPL accelerates cell proliferation, cell cycle, apoptosis, and glycolysis via the MEK1/2-ERK1/2 pathway in hepatocellular carcinoma.
  2. Overexpression of CENPL mRNA potentially regulated by miR-340-3p predicts the prognosis of pancreatic cancer patients.
    Title: Overexpression of CENPL mRNA potentially regulated by miR-340-3p predicts the prognosis of pancreatic cancer patients.
  3. Highly expressed centromere protein L indicates adverse survival and associates with immune infiltration in hepatocellular carcinoma.
    Title: Highly expressed centromere protein L indicates adverse survival and associates with immune infiltration in hepatocellular carcinoma.
  4. High mRNA Expression of CENPL and Its Significance in Prognosis of Hepatocellular Carcinoma Patients.
    Title: High mRNA Expression of CENPL and Its Significance in Prognosis of Hepatocellular Carcinoma Patients.
  5. Study demonstrate that the CENP-L-N complex plays a crucial role at the core of the 16-subunit Constitutive Centromere-Associated Network through interactions with CENP-C and CENP-H-I-KM.
    Title: The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31044, FLJ31786

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromosome segregation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of inner kinetochore IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
centromere protein L
Names
interphase centromere complex protein 33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127181.3 → NP_001120653.1  centromere protein L isoform 1

    See identical proteins and their annotated locations for NP_001120653.1

    Status: VALIDATED

    Source sequence(s)
    AL109921
    Consensus CDS
    CCDS44277.1
    UniProtKB/Swiss-Prot
    Q8N0S6
    Related
    ENSP00000348527.2, ENST00000356198.6
    Conserved Domains (1) summary
    pfam13092
    Location:223 → 369
    CENP-L; Kinetochore complex Sim4 subunit Fta1

  2. NM_001171182.2 → NP_001164653.1  centromere protein L isoform 2

    See identical proteins and their annotated locations for NP_001164653.1

    Status: VALIDATED

    Source sequence(s)
    AL109921
    Consensus CDS
    CCDS30938.1
    UniProtKB/Swiss-Prot
    Q5TEL5, Q8N0S6, Q96ND4
    Related
    ENSP00000323543.7, ENST00000345664.10
    Conserved Domains (1) summary
    pfam13092
    Location:177 → 323
    CENP-L; Kinetochore complex Sim4 subunit Fta1

  3. NM_001387284.1 → NP_001374213.1  centromere protein L isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL109921
    Consensus CDS
    CCDS44277.1
    Conserved Domains (1) summary
    pfam13092
    Location:223 → 369
    CENP-L; Kinetochore complex Sim4 subunit Fta1

  4. NM_001387285.1 → NP_001374214.1  centromere protein L isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL109921
    Consensus CDS
    CCDS44277.1
    Conserved Domains (1) summary
    pfam13092
    Location:223 → 369
    CENP-L; Kinetochore complex Sim4 subunit Fta1

  5. NM_001387286.1 → NP_001374215.1  centromere protein L isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL109921
    Consensus CDS
    CCDS44277.1
    Conserved Domains (1) summary
    pfam13092
    Location:223 → 369
    CENP-L; Kinetochore complex Sim4 subunit Fta1

  6. NM_001387287.1 → NP_001374216.1  centromere protein L isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL109921
    Consensus CDS
    CCDS30938.1
    UniProtKB/Swiss-Prot
    Q5TEL5, Q8N0S6, Q96ND4
    Related
    ENSP00000507473.1, ENST00000682279.1
    Conserved Domains (1) summary
    pfam13092
    Location:177 → 323
    CENP-L; Kinetochore complex Sim4 subunit Fta1

  7. NM_001387288.1 → NP_001374217.1  centromere protein L isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL109921
    Consensus CDS
    CCDS30938.1
    UniProtKB/Swiss-Prot
    Q5TEL5, Q8N0S6, Q96ND4
    Conserved Domains (1) summary
    pfam13092
    Location:177 → 323
    CENP-L; Kinetochore complex Sim4 subunit Fta1

  8. NM_001387289.1 → NP_001374218.1  centromere protein L isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL109921
    Consensus CDS
    CCDS30938.1
    UniProtKB/Swiss-Prot
    Q5TEL5, Q8N0S6, Q96ND4
    Conserved Domains (1) summary
    pfam13092
    Location:177 → 323
    CENP-L; Kinetochore complex Sim4 subunit Fta1

  9. NM_001387290.1 → NP_001374219.1  centromere protein L isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL109921
    Consensus CDS
    CCDS30938.1
    UniProtKB/Swiss-Prot
    Q5TEL5, Q8N0S6, Q96ND4
    Conserved Domains (1) summary
    pfam13092
    Location:177 → 323
    CENP-L; Kinetochore complex Sim4 subunit Fta1

  10. NM_001387291.1 → NP_001374220.1  centromere protein L isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL109921
    Conserved Domains (1) summary
    pfam13092
    Location:155 → 301
    CENP-L; Kinetochore complex Sim4 subunit Fta1

  11. NM_001387292.1 → NP_001374221.1  centromere protein L isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL109921

  12. NM_001387293.1 → NP_001374222.1  centromere protein L isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL109921

  13. NM_033319.4 → NP_201576.1  centromere protein L isoform 2

    See identical proteins and their annotated locations for NP_201576.1

    Status: VALIDATED

    Source sequence(s)
    AL109921
    Consensus CDS
    CCDS30938.1
    UniProtKB/Swiss-Prot
    Q5TEL5, Q8N0S6, Q96ND4
    Related
    ENSP00000356683.3, ENST00000367710.7
    Conserved Domains (1) summary
    pfam13092
    Location:177 → 323
    CENP-L; Kinetochore complex Sim4 subunit Fta1

RNA

  1. NR_170626.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL109921

  2. NR_170627.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL109921

  3. NR_170628.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL109921

  4. NR_170629.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL109921

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    173799550..173824883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    173157718..173183047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N0S6.2 GenPept UniProtKB/Swiss-Prot:Q8N0S6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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