U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CEP95 centrosomal protein 95 [ Homo sapiens (human) ]

Gene ID: 90799, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
CEP95provided by HGNC
Official Full Name
centrosomal protein 95provided by HGNC
Primary source
HGNC:HGNC:25141
See related
Ensembl:ENSG00000258890 AllianceGenome:HGNC:25141
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCDC45
Summary
Located in centrosome and spindle pole. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis (RPKM 9.3), bone marrow (RPKM 8.3) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CEP95 in Genome Data Viewer
Location:
17q23.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (64506762..64537946)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (65376722..65407705)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (62503095..62534064)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8843 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12595 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12596 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12597 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:62503269-62503885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12598 Neighboring gene microRNA 3064 Neighboring gene microRNA 5047 Neighboring gene DEAD-box helicase 5 Neighboring gene SMAD specific E3 ubiquitin protein ligase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8844 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8845 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8846 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:62658719-62659277 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:62702502-62703701 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12600 Neighboring gene MICOS10 pseudogene 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • DKFZp667E1824

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
centrosomal protein of 95 kDa
Names
centrosomal protein 95kDa
coiled-coil domain containing 45
coiled-coil domain-containing protein 45

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316990.2 → NP_001303919.1  centrosomal protein of 95 kDa isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon compared to variant 1, that causes translation initiation at a downstream AUG. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK297409, BC009518, BP357015
    UniProtKB/TrEMBL
    Q5JPF7
    Conserved Domains (1) summary
    cl23720
    Location:540 → 644
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  2. NM_138363.3 → NP_612372.1  centrosomal protein of 95 kDa isoform 1

    See identical proteins and their annotated locations for NP_612372.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC009518, BP357015
    Consensus CDS
    CCDS45763.1
    UniProtKB/Swiss-Prot
    B4DMD2, Q96GE4, Q96M81
    UniProtKB/TrEMBL
    A8K3H2
    Related
    ENSP00000450461.2, ENST00000556440.7
    Conserved Domains (2) summary
    cl00030
    Location:7 → 97
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cl25732
    Location:592 → 808
    SMC_N; RecF/RecN/SMC N terminal domain

RNA

  1. NR_133644.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate splice junctions compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL832822, BC009518, BP357015
    Related
    ENST00000553956.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    64506762..64537946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047437012.1 → XP_047292968.1  centrosomal protein of 95 kDa isoform X1

  2. XM_047437013.1 → XP_047292969.1  centrosomal protein of 95 kDa isoform X2

  3. XM_047437015.1 → XP_047292971.1  centrosomal protein of 95 kDa isoform X6

  4. XM_047437017.1 → XP_047292973.1  centrosomal protein of 95 kDa isoform X8

  5. XM_005257779.4 → XP_005257836.1  centrosomal protein of 95 kDa isoform X3

    UniProtKB/TrEMBL
    A8K3H2
    Conserved Domains (1) summary
    pfam13868
    Location:584 → 771
    TPH; Trichohyalin-plectin-homology domain

  6. XM_047437016.1 → XP_047292972.1  centrosomal protein of 95 kDa isoform X7

  7. XM_047437014.1 → XP_047292970.1  centrosomal protein of 95 kDa isoform X4

  8. XM_017025288.3 → XP_016880777.1  centrosomal protein of 95 kDa isoform X5

    Conserved Domains (1) summary
    TIGR02168
    Location:375 → 549
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RNA

  1. XR_007065529.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    65376722..65407705
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317711.1 → XP_054173686.1  centrosomal protein of 95 kDa isoform X1

  2. XM_054317712.1 → XP_054173687.1  centrosomal protein of 95 kDa isoform X2

  3. XM_054317716.1 → XP_054173691.1  centrosomal protein of 95 kDa isoform X6

  4. XM_054317718.1 → XP_054173693.1  centrosomal protein of 95 kDa isoform X8

  5. XM_054317713.1 → XP_054173688.1  centrosomal protein of 95 kDa isoform X3

  6. XM_054317717.1 → XP_054173692.1  centrosomal protein of 95 kDa isoform X7

  7. XM_054317714.1 → XP_054173689.1  centrosomal protein of 95 kDa isoform X4

  8. XM_054317715.1 → XP_054173690.1  centrosomal protein of 95 kDa isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96GE4.1 GenPept UniProtKB/Swiss-Prot:Q96GE4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools