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Lbr lamin B receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 89789, updated on 10-Jul-2024

Summary

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Official Symbol
Lbrprovided by RGD
Official Full Name
lamin B receptorprovided by RGD
Primary source
RGD:620813
See related
EnsemblRapid:ENSRNOG00000052574 AllianceGenome:RGD:620813
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
C14SR; Nbp60
Summary
Enables chaperone binding activity and nuclear localization sequence binding activity. Involved in mitotic cell cycle. Located in cytoplasm and nuclear envelope. Part of nuclear pore. Human ortholog(s) of this gene implicated in Greenberg dysplasia; Pelger-Huet anomaly; and primary biliary cholangitis. Orthologous to human LBR (lamin B receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 904.1), Spleen (RPKM 620.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Lbr in Genome Data Viewer
Location:
13q26
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (96071058..96095709, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (93539386..93564026, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (100431390..100450209, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 121, retrogene 1 Neighboring gene dynein axonemal heavy chain 14 Neighboring gene mitochondrial ribosomal protein S11, pseudogene 1 Neighboring gene 60S ribosomal protein L36a-like Neighboring gene ENAH, actin regulator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Autoantibodies from patients with primary biliary cirrhosis recognize a region within the nucleoplasmic domain of inner nuclear membrane protein LBR. Lin F, et al. Hepatology, 1996 Jan. PMID 8550049
  2. Purification of a 60 kDa nuclear localization signal binding protein in rat liver nuclear envelopes and characterization of its properties. Haino M, et al. J Biochem, 1993 Mar. PMID 8486604
  3. The Lamin B receptor is essential for cholesterol synthesis and perturbed by disease-causing mutations. Tsai PL, et al. Elife, 2016 Jun 23. PMID 27336722, Free PMC Article
  4. Reduced lymphocyte longevity and homeostatic proliferation in lamin B receptor-deficient mice results in profound and progressive lymphopenia. Verhagen AM, et al. J Immunol, 2012 Jan 1. PMID 22105998
  5. Mutations causing Greenberg dysplasia but not Pelger anomaly uncouple enzymatic from structural functions of a nuclear membrane protein. Clayton P, et al. Nucleus, 2010 Jul-Aug. PMID 21327084, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BEMAD was used on a purified nuclear pore complex preparation to map novel sites of O-GlcNAc modification on Lbr.
    Title: Mapping sites of O-GlcNAc modification using affinity tags for serine and threonine post-translational modifications.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables NADPH binding IEA
Inferred from Electronic Annotation
more info
  
enables NADPH binding ISO
Inferred from Sequence Orthology
more info
  
enables NADPH binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables chromo shadow domain binding IEA
Inferred from Electronic Annotation
more info
  
enables chromo shadow domain binding ISO
Inferred from Sequence Orthology
more info
  
enables delta14-sterol reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables delta14-sterol reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables delta14-sterol reductase activity ISO
Inferred from Sequence Orthology
more info
  
enables delta14-sterol reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nuclear localization sequence binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cholesterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neutrophil differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in neutrophil differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in neutrophil differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
  
is_active_in nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
delta(14)-sterol reductase LBR
Names
3-beta-hydroxysterol Delta (14)-reductase
C-14 sterol reductase
delta-14-SR
integral nuclear envelope inner membrane protein
sterol C14-reductase
NP_001380594.1
XP_038947059.1
XP_038947060.1
XP_038947061.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393665.1 → NP_001380594.1  delta(14)-sterol reductase LBR

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/TrEMBL
    A0A8I6AEP6, A6JGK3
    Related
    ENSRNOP00000090637.2, ENSRNOT00000095219.2
    Conserved Domains (2) summary
    pfam09465
    Location:1 → 55
    LBR_tudor; Lamin-B receptor of TUDOR domain
    cl21511
    Location:213 → 621
    PEMT; Phospholipid methyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    96071058..96095709 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091132.2 → XP_038947060.1  delta(14)-sterol reductase LBR isoform X1

    UniProtKB/TrEMBL
    A0A8I6AEP6, A6JGK3
    Conserved Domains (2) summary
    pfam09465
    Location:1 → 55
    LBR_tudor; Lamin-B receptor of TUDOR domain
    cl21511
    Location:213 → 621
    PEMT; Phospholipid methyltransferase

  2. XM_039091131.2 → XP_038947059.1  delta(14)-sterol reductase LBR isoform X1

    UniProtKB/TrEMBL
    A0A8I6AEP6, A6JGK3
    Conserved Domains (2) summary
    pfam09465
    Location:1 → 55
    LBR_tudor; Lamin-B receptor of TUDOR domain
    cl21511
    Location:213 → 621
    PEMT; Phospholipid methyltransferase

  3. XM_039091133.2 → XP_038947061.1  delta(14)-sterol reductase LBR isoform X1

    UniProtKB/TrEMBL
    A0A8I6AEP6, A6JGK3
    Conserved Domains (2) summary
    pfam09465
    Location:1 → 55
    LBR_tudor; Lamin-B receptor of TUDOR domain
    cl21511
    Location:213 → 621
    PEMT; Phospholipid methyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08984.1 GenPept UniProtKB/Swiss-Prot:O08984

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials