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sahH adenosylhomocysteinase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888746, updated on 6-Oct-2023

Summary

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Gene symbol
sahH
Gene description
adenosylhomocysteinase
Locus tag
Rv3248c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (3628160..3629647, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene two component DNA-binding response regulator MtrA Neighboring gene thymidylate kinase Neighboring gene TetR family transcriptional regulator Neighboring gene rubredoxin RubB Neighboring gene rubredoxin RubA Neighboring gene transmembrane alkane 1-monooxygenase AlkB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mycobacterium tuberculosis S-adenosyl-l-homocysteine hydrolase is negatively regulated by Ser/Thr phosphorylation. Corrales RM, et al. Biochem Biophys Res Commun, 2013 Jan 11. PMID 23178568
  2. Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors. Reddy MC, et al. Protein Sci, 2008 Dec. PMID 18815415, Free PMC Article
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SahH phosphorylation on Thr2 and Thr221 may represent a novel and presumably more general mechanism of regulation of the SAH/SAM balance in mycobacteria.
    Title: Mycobacterium tuberculosis S-adenosyl-l-homocysteine hydrolase is negatively regulated by Ser/Thr phosphorylation.
  2. crystal structure of SAHH, from in complex with adenosine and nicotinamide adenine dinucleotide; structures of complexes with three inhibitors are also reported
    Title: Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
adenosylhomocysteinase
NP_217765.1
  • S-adenosyl-L-homocysteine hydrolase (adohcyase)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3628160..3629647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217765.1 adenosylhomocysteinase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217765.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2I7WC09
    Conserved Domains (1) summary
    pfam05221
    Location:20 → 494
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
2ZIZ_A.1
2ZIZ_B.1
2ZIZ_C.1
2ZIZ_D.1
2ZJ0_A.1
2ZJ0_B.1
2ZJ0_C.1
2ZJ0_D.1
2ZJ1_A.1
2ZJ1_B.1
2ZJ1_C.1
2ZJ1_D.1
P9WGV3.1

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