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ideR iron-dependent repressor and activator IdeR [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 888590, updated on 11-Dec-2020

Summary

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Gene symbol
ideR
Gene description
iron-dependent repressor and activator IdeR
Locus tag
Rv2711
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
dtxR
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Genomic context

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Sequence:
NC_000962.3 (3023565..3024257)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene transmembrane protein Neighboring gene RNA polymerase sigma factor SigB Neighboring gene hypothetical protein Neighboring gene pyridine nucleotide transhydrogenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of truncated variants of the iron dependent transcriptional regulators from Corynebacterium diphtheriae and Mycobacterium tuberculosis. Oram DM, et al. FEMS Microbiol Lett, 2005 Feb 1. PMID 15667993
  2. Mechanism of Iron-Dependent Repressor (IdeR) Activation and DNA Binding: A Molecular Dynamics and Protein Structure Network Study. Ghosh S, et al. PLoS Comput Biol, 2015 Dec. PMID 26699663, Free PMC Article
  3. Zn(II) stimulation of Fe(II)-activated repression in the iron-dependent repressor from Mycobacterium tuberculosis. Stapleton B, et al. Biochemistry, 2013 Mar 19. PMID 23432191
  4. Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis. Wisedchaisri G, et al. Biochemistry, 2007 Jan 16. PMID 17209554
  5. Metal-linked dimerization in the iron-dependent regulator from Mycobacterium tuberculosis. Semavina M, et al. Biochemistry, 2006 Oct 17. PMID 17029403

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results elucidate the main mechanism of bfrB positive regulation by IdeR and identify Lsr2 as a new factor contributing to Fe homeostasis in mycobacteria.
    Title: The mycobacterial iron-dependent regulator IdeR induces ferritin (bfrB) by alleviating Lsr2 repression.
  2. Based on this study, a mechanistic model of IdeR activation and DNA binding has been proposed.
    Title: Mechanism of Iron-Dependent Repressor (IdeR) Activation and DNA Binding: A Molecular Dynamics and Protein Structure Network Study.
  3. Fe(II) binding was modestly weaker in the presence of Zn(II), but the coupled metal binding-DNA binding affinity was significantly stronger, requiring 30-fold less Fe(II) to activate DNA binding compared to Fe(II) alone.
    Title: Zn(II) stimulation of Fe(II)-activated repression in the iron-dependent repressor from Mycobacterium tuberculosis.
  4. analysis of the Mycobacterium tuberculosis iron-dependent regulator IdeR
    Title: Functional studies of the Mycobacterium tuberculosis iron-dependent regulator.
  5. dimerization is a major contributor to cooperative binding
    Title: Metal-linked dimerization in the iron-dependent regulator from Mycobacterium tuberculosis.
  6. The third domain of IdeR is required both for full DNA binding activity in vitro and for repressor activity in vivo
    Title: Analysis of truncated variants of the iron dependent transcriptional regulators from Corynebacterium diphtheriae and Mycobacterium tuberculosis.
  7. The 2D-IdeR-DNA complex structures confirm the specificity of Ser37 and Pro39 for thymine bases and suggest preferential contacts of Gln43 to cytosine bases of the DNA.
    Title: Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis.
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General gene information

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Homology

General protein information

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Preferred Names
iron-dependent repressor and activator IdeR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    3023565..3024257
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_217227.1 iron-dependent repressor and activator IdeR [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_217227.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P9WMH1
    UniProtKB/TrEMBL
    I6XF43
    Conserved Domains (2) summary
    smart00899
    Location:152 → 229
    FeoA; This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria
    COG1321
    Location:1 → 161
    MntR; Mn-dependent transcriptional regulator, DtxR family [Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WMH1.1

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