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vapC4 ribonuclease VapC4 [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 887835, updated on 6-Aug-2024

Summary

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Gene symbol
vapC4
Gene description
ribonuclease VapC4
Locus tag
Rv0595c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (694839..695231, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene Mce family protein Mce2D Neighboring gene Mce family lipoprotein LprL Neighboring gene Mce family protein Mce2F Neighboring gene antitoxin VapB4 Neighboring gene hypothetical protein Neighboring gene ribonuclease VapC27 Neighboring gene antitoxin VapB27

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mycobacterium tuberculosis VapC4 toxin engages small ORFs to initiate an integrated oxidative and copper stress response. Barth VC, et al. Proc Natl Acad Sci U S A, 2021 Aug 10. PMID 34362841, Free PMC Article
  2. Growth-regulating Mycobacterium tuberculosis VapC-mt4 toxin is an isoacceptor-specific tRNase. Cruz JW, et al. Nat Commun, 2015 Jul 9. PMID 26158745, Free PMC Article
  3. Growth and translation inhibition through sequence-specific RNA binding by Mycobacterium tuberculosis VapC toxin. Sharp JD, et al. J Biol Chem, 2012 Apr 13. PMID 22354968, Free PMC Article
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mycobacterium tuberculosis VapC4 toxin engages small ORFs to initiate an integrated oxidative and copper stress response.
    Title: Mycobacterium tuberculosis VapC4 toxin engages small ORFs to initiate an integrated oxidative and copper stress response.
  2. VapC-mt4 alters specific tRNAs to inhibit translation and modulate growth. This stress-linked activity of VapC-mt4 mirrors basic features of eukaryotic tRNases that also generate tRNA halves and inhibit translation in response to stress.
    Title: Growth-regulating Mycobacterium tuberculosis VapC-mt4 toxin is an isoacceptor-specific tRNase.
  3. The activity of VapC-mt4 is mechanistically distinct from other toxin-toxinS because it appears to primarily inhibit translation through selective, stable binding to RNA.
    Title: Growth and translation inhibition through sequence-specific RNA binding by Mycobacterium tuberculosis VapC toxin.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
ribonuclease VapC4
NP_215109.1
  • toxin, part of toxin-antitoxin (TA) operon with Rv0596c, contains PIN domain. This region is a possible MT-complex-specific genomic island (See Becq et al., 2007 PMID:17545187).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    694839..695231 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215109.1 ribonuclease VapC4 [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215109.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0E7TJ08, A0A0H3L612, Q7D9K6
    Conserved Domains (1) summary
    cd18768
    Location:7 → 129
    PIN_MtVapC4-C5-like; VapC-like PIN domain of Mycobacterium tuberculosis VapC4, VapC5, and related proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O07783.3

Gene LinkOut

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