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prsA ribose-phosphate pyrophosphokinase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885993, updated on 6-Oct-2023

Summary

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Gene symbol
prsA
Gene description
ribose-phosphate pyrophosphokinase
Locus tag
Rv1017c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (1135501..1136481, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene 50S ribosomal protein L25/general stress protein Ctc Neighboring gene lipoprotein LpqT Neighboring gene bifunctional UDP-N-acetylglucosamine pyrophosphorylase/glucosamine-1-phosphate N-acetyltransferase Neighboring gene tRNA-Gln

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mycobacterium tuberculosis phosphoribosylpyrophosphate synthetase: biochemical features of a crucial enzyme for mycobacterial cell wall biosynthesis. Lucarelli AP, et al. PLoS One, 2010 Nov 15. PMID 21085589, Free PMC Article
  2. Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetase. Alderwick LJ, et al. Glycobiology, 2011 Apr. PMID 21045009, Free PMC Article
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. a detailed biochemical and biophysical study of Mt-PrsA, which exhibits the most rapid enzyme kinetics reported for a pRpp synthetase
    Title: Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetase.
  2. Studies indicate that the characterization of PRPPase (rv1017c gene prsA) provides the starting point for the development of inhibitors for antitubercular drug design.
    Title: Mycobacterium tuberculosis phosphoribosylpyrophosphate synthetase: biochemical features of a crucial enzyme for mycobacterial cell wall biosynthesis.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
ribose-phosphate pyrophosphokinase
NP_215533.1
  • phosphoribosyl pyrophosphate synthetase (PRPP synthetase). Belongs to the ribose-phosphate pyrophosphokinase family. Cofactor: both inorganic phosphate and magnesium ion are required for enzyme stability and activity (by similarity).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1135501..1136481 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_215533.1 ribose-phosphate pyrophosphokinase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_215533.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4M414
    Conserved Domains (1) summary
    PRK03092
    Location:23 → 326
    PRK03092; ribose-phosphate diphosphokinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WKE3.1

Gene LinkOut

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Molecular Biology Databases