U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

lsr2 iron-regulated H-NS-like protein [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885580, updated on 12-Feb-2021

Summary

Go to the top of the page Help
Gene symbol
lsr2
Gene description
iron-regulated H-NS-like protein
Locus tag
Rv3597c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000962.3 (4040981..4041319, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene PE-PGRS family protein PE_PGRS59 Neighboring gene ATP-dependent protease ATP-binding subunit ClpC Neighboring gene lysine--tRNA ligase Neighboring gene type III pantothenate kinase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mechanism of DNA organization by Mycobacterium tuberculosis protein Lsr2. Qu Y, et al. Nucleic Acids Res, 2013 May 1. PMID 23580555, Free PMC Article
  2. Lsr2 is a nucleoid-associated protein that targets AT-rich sequences and virulence genes in Mycobacterium tuberculosis. Gordon BR, et al. Proc Natl Acad Sci U S A, 2010 Mar 16. PMID 20133735, Free PMC Article
  3. The multifunctional histone-like protein Lsr2 protects mycobacteria against reactive oxygen intermediates. Colangeli R, et al. Proc Natl Acad Sci U S A, 2009 Mar 17. PMID 19237572, Free PMC Article
  4. The mycobacterial iron-dependent regulator IdeR induces ferritin (bfrB) by alleviating Lsr2 repression. Kurthkoti K, et al. Mol Microbiol, 2015 Dec. PMID 26268801, Free PMC Article
  5. Lsr2 of Mycobacterium represents a novel class of H-NS-like proteins. Gordon BR, et al. J Bacteriol, 2008 Nov. PMID 18776007, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results elucidate the main mechanism of bfrB positive regulation by IdeR and identify Lsr2 as a new factor contributing to Fe homeostasis in mycobacteria.
    Title: The mycobacterial iron-dependent regulator IdeR induces ferritin (bfrB) by alleviating Lsr2 repression.
  2. This report shows that Lsr2 cooperatively binds to DNA forming a rigid Lsr2 nucleoprotein complex that restricts DNA accessibility, similar to H-NS.
    Title: Mechanism of DNA organization by Mycobacterium tuberculosis protein Lsr2.
  3. Lsr2 of Mycobacterium tuberculosis is a unique nucleoid-associated protein that binds AT-rich regions of the genome.
    Title: Lsr2 is a nucleoid-associated protein that targets AT-rich sequences and virulence genes in Mycobacterium tuberculosis.
  4. Lsr2 shields DNA from reactive intermediates by binding bacterial DNA and physically protecting it
    Title: The multifunctional histone-like protein Lsr2 protects mycobacteria against reactive oxygen intermediates.
  5. The results demonstrate unequivocally that Lsr2 is an H-NS-like protein.
    Title: Lsr2 of Mycobacterium represents a novel class of H-NS-like proteins.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

General protein information

Go to the top of the page Help
Preferred Names
iron-regulated H-NS-like protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    4040981..4041319 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_218114.1 iron-regulated H-NS-like protein [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_218114.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P9WIP7
    UniProtKB/TrEMBL
    I6X7R6
    Conserved Domains (1) summary
    pfam11774
    Location:1 → 111
    Lsr2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WIP7.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases