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dnaA chromosomal replication initiator protein DnaA [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885041, updated on 6-Oct-2023

Summary

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Gene symbol
dnaA
Gene description
chromosomal replication initiator protein DnaA
Locus tag
Rv0001
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (1..1524)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene DNA polymerase III subunit beta Neighboring gene DNA replication/repair protein RecF Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Propionate represses the dnaA gene via the methylcitrate pathway-regulating transcription factor, PrpR, in Mycobacterium tuberculosis. Masiewicz P, et al. Antonie Van Leeuwenhoek, 2014 May. PMID 24705740, Free PMC Article
  2. Characterization of physical interaction between replication initiator protein DnaA and replicative helicase from Mycobacterium tuberculosis H37Rv. Xie Y, et al. Biochemistry (Mosc), 2009 Dec. PMID 19961412
  3. Structural and thermodynamic signatures of DNA recognition by Mycobacterium tuberculosis DnaA. Tsodikov OV, et al. J Mol Biol, 2011 Jul 15. PMID 21620858
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here, the authors report for the first time that PrpR also regulates the dnaA gene, which encodes the DnaA initiator protein responsible for initiating chromosomal replication.
    Title: Propionate represses the dnaA gene via the methylcitrate pathway-regulating transcription factor, PrpR, in Mycobacterium tuberculosis.
  2. Data demonstrate that the decrease in the affinity of the MtDnaA-box variants for MtDnaA DBD relative to that of the highest-affinity box TTGTCCACA is less than 10-fold.
    Title: Structural and thermodynamic signatures of DNA recognition by Mycobacterium tuberculosis DnaA.
  3. a physical interaction between DnaA and replicative helicase DnaB from M. tuberculosis is shown the role in subsequent DnaA-OriC interactions.
    Title: Characterization of physical interaction between replication initiator protein DnaA and replicative helicase from Mycobacterium tuberculosis H37Rv.
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General gene information

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Homology

General protein information

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Preferred Names
chromosomal replication initiator protein DnaA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1..1524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_214515.1 chromosomal replication initiator protein DnaA [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_214515.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4LQU1
    Conserved Domains (1) summary
    PRK14086
    Location:1 → 504
    dnaA; chromosomal replication initiator protein DnaA
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WNW3.1

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Research Materials