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exoY adenylate cyclase [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 879421, updated on 24-Aug-2024

Summary

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Gene symbol
exoY
Gene description
adenylate cyclase
Locus tag
PA2191
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (2410344..2411480, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hydrogen cyanide synthase subunit HcnA Neighboring gene hydrogen cyanide synthase subunit HcnB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Role of Pseudomonas aeruginosa ExoY in an Acute Mouse Lung Infection Model. Kloth C, et al. Toxins (Basel), 2018 May 4. PMID 29734720, Free PMC Article
  2. ExoY from Pseudomonas aeruginosa is a nucleotidyl cyclase with preference for cGMP and cUMP formation. Beckert U, et al. Biochem Biophys Res Commun, 2014 Jul 18. PMID 24971548, Free PMC Article
  3. Adenylate cyclase activity of Pseudomonas aeruginosa ExoY can mediate bleb-niche formation in epithelial cells and contributes to virulence. Hritonenko V, et al. Microb Pathog, 2011 Nov. PMID 21843628, Free PMC Article
  4. Actin cytoskeleton disruption by ExoY and its effects on Pseudomonas aeruginosa invasion. Cowell BA, et al. FEMS Microbiol Lett, 2005 Sep 1. PMID 16039071
  5. Paradoxical cAMP-induced lung endothelial hyperpermeability revealed by Pseudomonas aeruginosa ExoY. Sayner SL, et al. Circ Res, 2004 Jul 23. PMID 15192021

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our results suggest that the nucleotidyl cyclase activity of ExoY can contribute to P. aeruginosa acute pathogenicity.
    Title: The Role of Pseudomonas aeruginosa ExoY in an Acute Mouse Lung Infection Model.
  2. Here, we report that Pseudomonas aeruginosa ExoY inhibits proinflammatory cytokine production through suppressing the activation of TAK1 as well as downstream NF-kappaB and mitogen-activated protein (MAP) kinases.
    Title: Bacterial Nucleotidyl Cyclase Inhibits the Host Innate Immune Response by Suppressing TAK1 Activation.
  3. Thus, ExoY is a nucleotidyl cyclase with preference for cGMP and cUMP production
    Title: ExoY from Pseudomonas aeruginosa is a nucleotidyl cyclase with preference for cGMP and cUMP formation.
  4. Adenylate cyclase activity of ExoY mediates bleb-niche formation in epithelial cells and contributes to virulence.
    Title: Adenylate cyclase activity of Pseudomonas aeruginosa ExoY can mediate bleb-niche formation in epithelial cells and contributes to virulence.
  5. actin disruption of epithelial cells at 2 h post-infection associated with both adenylate cyclase-active ExoY and its catalytic mutant form ExoYK81M, and which coincided with inhibition of bacterial invasion
    Title: Actin cytoskeleton disruption by ExoY and its effects on Pseudomonas aeruginosa invasion.
  6. ExoY synthesizes a cAMP pool that is distinct from the endogenous pool in its location and regulation by phosphodiesterases. ExoY-induced cAMP elevations are endothelial barrier disruptive, in contrast to endogenous cAMP which is barrier protective.
    Title: Paradoxical cAMP-induced lung endothelial hyperpermeability revealed by Pseudomonas aeruginosa ExoY.
  7. Role in systemic spread of Pseudomonas aeruginosa PAO1 in vivo
    Title: Role of the type III secreted exoenzymes S, T, and Y in systemic spread of Pseudomonas aeruginosa PAO1 in vivo.
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General gene information

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Homology

General protein information

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Preferred Names
adenylate cyclase
NP_250881.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    2410344..2411480 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_250881.1 adenylate cyclase [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_250881.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6B7EIT3
    Conserved Domains (1) summary
    pfam03497
    Location:37 → 202
    Anthrax_toxA; Anthrax toxin LF subunit
Nucleotide Protein
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