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algD GDP-mannose 6-dehydrogenase AlgD [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 879004, updated on 11-Sep-2024

Summary

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Gene symbol
algD
Gene description
GDP-mannose 6-dehydrogenase AlgD
Locus tag
PA3540
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (3962825..3964135)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene ABC transporter ATP-binding protein Neighboring gene hypothetical protein Neighboring gene glycosyltransferase alg8 Neighboring gene alginate biosynthesis protein Alg44

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inactivation of GDP-mannose dehydrogenase from Pseudomonas aeruginosa by penicillic acid identifies a critical active site loop. Kimmel JL, et al. Arch Biochem Biophys, 2005 Sep 15. PMID 16111644
  2. [The influence of lysogenic phage on biofilm formation of Pseudomonas aeruginosa]. Du BZ, et al. Sichuan Da Xue Xue Bao Yi Xue Ban, 2008 Nov. PMID 19253818
  3. The NtrC family regulator AlgB, which controls alginate biosynthesis in mucoid Pseudomonas aeruginosa, binds directly to the algD promoter. Leech AJ, et al. J Bacteriol, 2008 Jan. PMID 17981963, Free PMC Article
  4. Relative expression of Pseudomonas aeruginosa virulence genes analyzed by a real time RT-PCR method during lung infection in rats. Joly B, et al. FEMS Microbiol Lett, 2005 Feb 1. PMID 15668029
  5. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The lysogenic phage Ppa3094 could influence biofilm formation by changing the expressing level of the alginate biosynthetic genes AlgC and AlgD.
    Title: [The influence of lysogenic phage on biofilm formation of Pseudomonas aeruginosa].
  2. AlgB belongs to a subclass of NtrC family proteins that can activate promoters which utilize a sigma factor other than 54, in this case to stimulate transcription from the Sigma 22-dependent algD promoter.
    Title: The NtrC family regulator AlgB, which controls alginate biosynthesis in mucoid Pseudomonas aeruginosa, binds directly to the algD promoter.
  3. Cys 246 is adjacent to the GDP-mannose binding loop, and its alkylation may also interfere with loop movement.
    Title: Inactivation of GDP-mannose dehydrogenase from Pseudomonas aeruginosa by penicillic acid identifies a critical active site loop.
  4. Transcription of algD occurred on the 4th day of lung infections and increased regularly over time.
    Title: Relative expression of Pseudomonas aeruginosa virulence genes analyzed by a real time RT-PCR method during lung infection in rats.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables GDP-mannose 6-dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within alginic acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within alginic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to cell envelope stress IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to abiotic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to biotic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to osmotic stress IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within single-species biofilm formation IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
GDP-mannose 6-dehydrogenase AlgD
NP_252230.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    3962825..3964135
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_252230.1 GDP-mannose 6-dehydrogenase AlgD [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_252230.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2R3IVI3
    Conserved Domains (1) summary
    COG1004
    Location:1 → 426
    Ugd; UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11759.2

Gene LinkOut

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Molecular Biology Databases