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lon Lon protease [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 877926, updated on 24-Aug-2024

Summary

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Gene symbol
lon
Gene description
Lon protease
Locus tag
PA1803
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (1956227..1958623)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene ATP-dependent Clp protease proteolytic subunit Neighboring gene ATP-dependent protease ATP-binding subunit ClpX Neighboring gene DNA-binding protein HU Neighboring gene tRNA-Asp

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Lon protease is essential for full virulence in Pseudomonas aeruginosa. Breidenstein EB, et al. PLoS One, 2012. PMID 23145092, Free PMC Article
  2. The Lon protease of Pseudomonas aeruginosa is induced by aminoglycosides and is involved in biofilm formation and motility. Marr AK, et al. Microbiology (Reading), 2007 Feb. PMID 17259618
  3. The Crc protein participates in down-regulation of the Lon gene to promote rhamnolipid production and rhl quorum sensing in Pseudomonas aeruginosa. Yang N, et al. Mol Microbiol, 2015 May. PMID 25641250
  4. Controlled high-level expression of the lon gene of Escherichia coli allows overproduction of Lon protease. Thomas CD, et al. Gene, 1993 Dec 22. PMID 8294008
  5. Negative regulation of quorum-sensing systems in Pseudomonas aeruginosa by ATP-dependent Lon protease. Takaya A, et al. J Bacteriol, 2008 Jun. PMID 18408026, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study therefore uncovers a novel posttranscriptional regulatory cascade, Crc-Hfq/Lon/RhlI, for the regulation of rhamnolipid production and rhl quorum sensing in Pseudomonas aeruginosa.
    Title: The Crc protein participates in down-regulation of the Lon gene to promote rhamnolipid production and rhl quorum sensing in Pseudomonas aeruginosa.
  2. Data suggested that Lon protease is a powerful negative regulator of both HSL-mediated QS systems in P. aeruginosa.
    Title: Negative regulation of quorum-sensing systems in Pseudomonas aeruginosa by ATP-dependent Lon protease.
  3. Studies with a lon mutant compared to its parent and a complemented strain indicated that this protein was essential for biofilm formation and motility in P. aeruginosa and is induced by aminoglycosides.
    Title: The Lon protease of Pseudomonas aeruginosa is induced by aminoglycosides and is involved in biofilm formation and motility.
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General gene information

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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables ATP-dependent peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within bacterial-type flagellum-dependent swarming motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within bacterial-type flagellum-dependent swimming motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellular response to antibiotic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein secretion by the type III secretion system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within single-species biofilm formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within type IV pilus-dependent motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Lon protease
NP_250494.1
  • Product name confidence: class 2 (High similarity to functionally studied protein)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    1956227..1958623
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_250494.1 Lon protease [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_250494.1

    Status: PROVISIONAL

    Conserved Domains (1) summary
    COG0466
    Location:2 → 774
    Lon; ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein
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