U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mexR multidrug resistance operon repressor MexR [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 877857, updated on 11-Sep-2024

Summary

Go to the top of the page Help
Gene symbol
mexR
Gene description
multidrug resistance operon repressor MexR
Locus tag
PA0424
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_002516.2 (471306..471749, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene multidrug resistance protein MexA Neighboring gene multidrug resistance protein MexB

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mutation-Induced Population Shift in the MexR Conformational Ensemble Disengages DNA Binding: A Novel Mechanism for MarR Family Derepression. Anandapadamanaban M, et al. Structure, 2016 Aug 2. PMID 27427478
  2. Expression of the multidrug resistance operon mexA-mexB-oprM in Pseudomonas aeruginosa: mexR encodes a regulator of operon expression. Poole K, et al. Antimicrob Agents Chemother, 1996 Sep. PMID 8878574, Free PMC Article
  3. Influence of mutations in the mexR repressor gene on expression of the MexA-MexB-oprM multidrug efflux system of Pseudomonas aeruginosa. Srikumar R, et al. J Bacteriol, 2000 Mar. PMID 10671465, Free PMC Article
  4. Mutation in mexR-gene leading to drug resistance in corneal keratitis in human. Suman G, et al. Indian J Exp Biol, 2006 Nov. PMID 17205717
  5. Structural insight into the oxidation-sensing mechanism of the antibiotic resistance of regulator MexR. Chen H, et al. EMBO Rep, 2010 Sep. PMID 20616806, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sulfane Sulfur is an intrinsic signal activating MexR-regulated antibiotic resistance in Pseudomonas aeruginosa.
    Title: Sulfane Sulfur is an intrinsic signal activating MexR-regulated antibiotic resistance in Pseudomonas aeruginosa.
  2. Mutation-induced population shift in the MexR conformational ensemble disengages DNA binding.
    Title: Mutation-Induced Population Shift in the MexR Conformational Ensemble Disengages DNA Binding: A Novel Mechanism for MarR Family Derepression.
  3. MexR termination has a role in overexpression of MexAB-OprM efflux pump in Pseudomonas aeruginosa
    Title: Premature Termination of MexR Leads to Overexpression of MexAB-OprM Efflux Pump in Pseudomonas aeruginosa in a Tertiary Referral Hospital in India.
  4. Pentachlorophenol induction of the Pseudomonas aeruginosa mexAB-oprM efflux operon involves repressors NalC and MexR and the antirepressor ArmR
    Title: Pentachlorophenol induction of the Pseudomonas aeruginosa mexAB-oprM efflux operon: involvement of repressors NalC and MexR and the antirepressor ArmR.
  5. Data describe the crystal structure of MexR in its oxidized form at a resolution of 2.1 A, and the mechanism by which oxidative signal allosterically derepresses the MexR-controlled transcription activation.
    Title: Structural insight into the oxidation-sensing mechanism of the antibiotic resistance of regulator MexR.
  6. Mutation in mexR-gene leading to drug resistance in corneal keratitis in human.
    Title: Mutation in mexR-gene leading to drug resistance in corneal keratitis in human.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by PseudoCAP

Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
multidrug resistance operon repressor MexR
NP_249115.1
  • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    471306..471749 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_249115.1 multidrug resistance operon repressor MexR [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_249115.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A172W5B8, C7EX06
    Conserved Domains (1) summary
    smart00347
    Location:29 → 128
    HTH_MARR; helix_turn_helix multiple antibiotic resistance protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52003.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials