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hmgA homogentisate 1,2-dioxygenase [ Pseudomonas aeruginosa PAO1 ]

Gene ID: 877745, updated on 24-Aug-2024

Summary

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Gene symbol
hmgA
Gene description
homogentisate 1,2-dioxygenase
Locus tag
PA2009
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Pseudomonas aeruginosa PAO1 (strain: PAO1)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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Genomic context

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Sequence:
NC_002516.2 (2197432..2198730, complement)

NC_002516.2Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily transporter Neighboring gene maleylacetoacetate isomerase Neighboring gene fumarylacetoacetase Neighboring gene transcriptional regulator Neighboring gene 3-hydroxy-3-isohexenylglutaryl-CoA/hydroxy-methylglutaryl-CoA lyase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_002516.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Homogentisate 1-2-Dioxygenase Downregulation in the Chronic Persistence of Pseudomonas aeruginosa Australian Epidemic Strain-1 in the CF Lung. Harmer CJ, et al. PLoS One, 2015. PMID 26252386, Free PMC Article
  2. Inactivation of the hmgA gene of Pseudomonas aeruginosa leads to pyomelanin hyperproduction, stress resistance and increased persistence in chronic lung infection. Rodríguez-Rojas A, et al. Microbiology (Reading), 2009 Apr. PMID 19332807
  3. Molecular characterization of a gene encoding a homogentisate dioxygenase from Aspergillus nidulans and identification of its human and plant homologues. Fernández-Cañón JM, et al. J Biol Chem, 1995 Sep 8. PMID 7673153
  4. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
  5. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study suggests that hmgA may have a role in P. aeruginosa persistence in chronic infection and the results provide a starting point for clarifying the role of hmgA in chronic Australian Epidemic Strain.[hmgA]
    Title: Homogentisate 1-2-Dioxygenase Downregulation in the Chronic Persistence of Pseudomonas aeruginosa Australian Epidemic Strain-1 in the CF Lung.
  2. Our results clearly demonstrate that hmgA inactivation leads to a better adaptation to chronic lung infection.
    Title: Inactivation of the hmgA gene of Pseudomonas aeruginosa leads to pyomelanin hyperproduction, stress resistance and increased persistence in chronic lung infection.
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General gene information

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Homology

Gene Ontology Provided by PseudoCAP

Function Evidence Code Pubs
enables homogentisate 1,2-dioxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within L-phenylalanine catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
homogentisate 1,2-dioxygenase
NP_250699.1
  • Product name confidence: class 2 (High similarity to functionally studied protein)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_002516.2 Reference assembly

    Range
    2197432..2198730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_250699.1 homogentisate 1,2-dioxygenase [Pseudomonas aeruginosa PAO1]

    See identical proteins and their annotated locations for NP_250699.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q9X4G0
    Conserved Domains (1) summary
    PRK05341
    Location:5 → 432
    PRK05341; homogentisate 1,2-dioxygenase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9X4G0.2

Gene LinkOut

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