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RAB11A RAB11A, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 8766, updated on 14-Nov-2024

Summary

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Official Symbol
RAB11Aprovided by HGNC
Official Full Name
RAB11A, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:9760
See related
Ensembl:ENSG00000103769 MIM:605570; AllianceGenome:HGNC:9760
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
YL8
Summary
The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Expression
Ubiquitous expression in esophagus (RPKM 50.5), adrenal (RPKM 37.5) and 25 other tissues See more
Orthologs
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Genomic context

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See RAB11A in Genome Data Viewer
Location:
15q22.31
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (65869491..65891989)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (63678915..63701413)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (66161829..66184327)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370866 Neighboring gene uncharacterized LOC124903586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9607 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9608 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6561 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9609 Neighboring gene tRNA-Gln (anticodon CTG) 1-4 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:66194834-66194998 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:66195001-66195792 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66214128-66214697 Neighboring gene multiple EGF like domains 11 Neighboring gene Sharpr-MPRA regulatory region 15210 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:66246132-66246645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66249429-66249932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66249933-66250434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66256890-66257866 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66272648-66273148 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66273149-66273649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66274440-66274940 Neighboring gene uncharacterized LOC105370867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66315774-66316274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66316275-66316775 Neighboring gene microRNA 4311

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Role of the Rab11 pathway in negative-strand virus assembly. Bruce EA, et al. Biochem Soc Trans, 2012 Dec 1. PMID 23176490
  2. RAB11A aggravates PDGF-BB-stimulated proliferation, migration, and inflammation of airway smooth muscle cells via affecting the NF-κB and PI3K/AKT pathways. Gong Y, et al. Allergol Immunopathol (Madr), 2022. PMID 35789415
  3. RAB11A Expression Is Associated With Cancer Aggressiveness Through Regulation of FGFR-Signaling in Lung Squamous Cell Carcinoma. Gombodorj N, et al. Ann Surg Oncol, 2022 Oct. PMID 35644860
  4. Quantitative live cell imaging reveals influenza virus manipulation of Rab11A transport through reduced dynein association. Bhagwat AR, et al. Nat Commun, 2020 Jan 7. PMID 31911620, Free PMC Article
  5. Loss of endosomal recycling factor RAB11 coupled with complex regulation of MAPK/ERK/AKT signaling in postmortem spinal cord specimens of sporadic amyotrophic lateral sclerosis patients. Mitra J, et al. Mol Brain, 2019 Jun 13. PMID 31196199, Free PMC Article

See all (281) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cohort Expansion and Genotype-Phenotype Analysis of RAB11A-Associated Neurodevelopmental Disorder.
    Title: Cohort Expansion and Genotype-Phenotype Analysis of RAB11A-Associated Neurodevelopmental Disorder.
  2. Coxiella burnetii-containing vacuoles interact with host recycling endosomal proteins Rab11a and Rab35 for vacuolar expansion and bacterial growth.
    Title: Coxiella burnetii-containing vacuoles interact with host recycling endosomal proteins Rab11a and Rab35 for vacuolar expansion and bacterial growth.
  3. Stress-induced Rab11a-exosomes induce amphiregulin-mediated cetuximab resistance in colorectal cancer.
    Title: Stress-induced Rab11a-exosomes induce amphiregulin-mediated cetuximab resistance in colorectal cancer.
  4. Rab11 suppresses head and neck carcinoma by regulating EGFR and EpCAM exosome secretion.
    Title: Rab11 suppresses head and neck carcinoma by regulating EGFR and EpCAM exosome secretion.
  5. Rab11 and Its Role in Neurodegenerative Diseases.
    Title: Rab11 and Its Role in Neurodegenerative Diseases.
  6. SREBP2/Rab11s/GLUT1/6 network regulates proliferation and migration of glioblastoma.
    Title: SREBP2/Rab11s/GLUT1/6 network regulates proliferation and migration of glioblastoma.
  7. Rab11a promotes the malignant progression of ovarian cancer by inducing autophagy.
    Title: Rab11a promotes the malignant progression of ovarian cancer by inducing autophagy.
  8. RAB11A Expression Is Associated With Cancer Aggressiveness Through Regulation of FGFR-Signaling in Lung Squamous Cell Carcinoma.
    Title: RAB11A Expression Is Associated With Cancer Aggressiveness Through Regulation of FGFR-Signaling in Lung Squamous Cell Carcinoma.
  9. RAB11A aggravates PDGF-BB-stimulated proliferation, migration, and inflammation of airway smooth muscle cells via affecting the NF-kappaB and PI3K/AKT pathways.
    Title: RAB11A aggravates PDGF-BB-stimulated proliferation, migration, and inflammation of airway smooth muscle cells via affecting the NF-κB and PI3K/AKT pathways.
  10. TBC1 domain family member 23 interacts with Ras-related protein Rab-11A to promote poor prognosis of non-small-cell lung cancer via beta1-integrin.
    Title: TBC1 domain family member 23 interacts with Ras-related protein Rab-11A to promote poor prognosis of non-small-cell lung cancer via β1-integrin.
Submit: New GeneRIF Correction See all GeneRIFs (104)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of RAB11A, member RAS oncogene family (RAB11A) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed
Knockdown of RAB11A, member RAS oncogene family (RAB11A) by siRNA inhibits HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with RAB11A; predicted interaction to be relevant to vesicular transport/membrane trafficking PubMed
Nef nef HIV-1 Nef co-localization with Rab11A GTPase is revealed by staining in the peripheral and perinuclear compartments PubMed
nef RAB11(Q67L) mutant induces significant reversal of HLA-I A2 downregulation by HIV-1 Nef through redistributing HLA-I A2 from the perinuclear vesicles to the peripheral punctate vesicles at the plasma membrane PubMed
Pr55(Gag) gag Rab11a modulates intracellular Gag expression in human cells PubMed
gag HIV-1 Gag and viral RNA preferentially co-localize with multivesicular bodies and Rab11a endosomes PubMed
capsid gag Overexpression of a dominant negative Rab-11 GTPase mutant reduces the release of HIV-1 by CA levels and increases the intracellular CA accumulation PubMed
reverse transcriptase gag-pol The highest RT activity is found in Rab11a compartments and Rab7a compartments in nontreated cells after 7 and 14 days of HIV-1 challenge, respectively, suggesting that the virus is mainly located in these endosomal compartments PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC1490

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein activity IC
Inferred by Curator
more info
 PubMed 
enables G protein activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dynein light intermediate chain binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables myosin V binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables syntaxin binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport IC
Inferred by Curator
more info
 PubMed 
involved_in amyloid-beta clearance by transcytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in astral microtubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in early endosome to recycling endosome transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of protein localization to membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of protein localization to organelle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of vesicle localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exosomal secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in melanosome transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in melanosome transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic metaphase chromosome alignment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic spindle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in multivesicular body assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane to endosome transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic cytokinetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to cell surface IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to cilium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cilium assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of early endosome to recycling endosome transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of endocytic recycling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of protein localization to centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of vesicle-mediated transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus HDA PubMed 
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
  
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle membrane TAS
Traceable Author Statement
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in endocytic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
colocalizes_with kinetochore microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in multivesicular body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic recycling endosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in recycling endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in recycling endosome membrane TAS
Traceable Author Statement
more info
  
located_in spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in trans-Golgi network membrane IC
Inferred by Curator
more info
 PubMed 
located_in trans-Golgi network membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ras-related protein Rab-11A
Names
RAB 11A, member oncogene family
rab-11
NP_001193765.1
NP_004654.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206836.2 → NP_001193765.1  ras-related protein Rab-11A isoform 2

    See identical proteins and their annotated locations for NP_001193765.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC084854, AK300008, BC013348, BC047114, DC300743
    Consensus CDS
    CCDS58373.1
    UniProtKB/TrEMBL
    H3BMH2
    Related
    ENSP00000456420.1, ENST00000569896.1
    Conserved Domains (1) summary
    cd01868
    Location:9 → 146
    Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25

  2. NM_004663.5 → NP_004654.1  ras-related protein Rab-11A isoform 1

    See identical proteins and their annotated locations for NP_004654.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC084854, BC013348, BC047114, DC300743
    Consensus CDS
    CCDS10212.1
    UniProtKB/Swiss-Prot
    B2R4B6, B4DT13, P24410, P62491, Q5TZN9, Q9JLX1
    UniProtKB/TrEMBL
    B4DMN1
    Related
    ENSP00000261890.2, ENST00000261890.7
    Conserved Domains (1) summary
    cd01868
    Location:9 → 173
    Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    65869491..65891989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    63678915..63701413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62491.3 GenPept UniProtKB/Swiss-Prot:P62491

Gene LinkOut

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