FAU1 5-formyltetrahydrofolate cyclo-ligase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: FAU1
Official Full Name: 5-formyltetrahydrofolate cyclo-ligase
Primary source: SGD:S000000985
Locus tag: YER183C
See related: AllianceGenome:SGD:S000000985; FungiDB:YER183C; VEuPathDB:YER183C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 5-formyltetrahydrofolate cyclo-ligase activity. Involved in folic acid-containing compound biosynthetic process. Located in mitochondrion. Orthologous to human MTHFS (methenyltetrahydrofolate synthetase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See FAU1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (553334..553969, complement)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 5-formyltetrahydrofolate cyclo-ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5-formyltetrahydrofolate cyclo-ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables 5-formyltetrahydrofolate cyclo-ligase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in folic acid-containing compound biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in folic acid-containing compound biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in tetrahydrofolate interconversion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 5-formyltetrahydrofolate cyclo-ligase

NP_011110.1

EC 6.3.3.2

5,10-methenyltetrahydrofolate synthetase; involved in folic acid biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

553334..553969 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179073.1 → NP_011110.1 TPA: 5-formyltetrahydrofolate cyclo-ligase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011110.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DM92, P40099

UniProtKB/TrEMBL

A6ZRE0, B3LRU3, B5VHW4, C7GUZ3

Conserved Domains (1) summary

pfam01812
Location:4 → 203

5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family