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BUR6 negative cofactor 2 transcription regulator complex subunit BUR6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856904, updated on 14-Nov-2024

Summary

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Official Symbol
BUR6
Official Full Name
negative cofactor 2 transcription regulator complex subunit BUR6
Primary source
SGD:S000000961
Locus tag
YER159C
See related
AllianceGenome:SGD:S000000961; FungiDB:YER159C; VEuPathDB:YER159C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NCB1
Summary
Enables chromatin binding activity; core promoter sequence-specific DNA binding activity; and transcription coregulator activity. Contributes to TBP-class protein binding activity. Involved in RNA polymerase II preinitiation complex assembly; cellular response to heat; and regulation of transcription by RNA polymerase II. Part of negative cofactor 2 complex. Orthologous to human DRAP1 (DR1 associated protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See BUR6 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (491530..491958, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene tRNA-Glu Neighboring gene uncharacterized protein Neighboring gene tRNA-Arg Neighboring gene gag-pol fusion protein Neighboring gene gag protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Dr1/DRAP1 heterodimer is a global repressor of transcription in vivo. Kim S, et al. Proc Natl Acad Sci U S A, 1997 Feb 4. PMID 9023340, Free PMC Article
  2. Saccharomyces cerevisiae BUR6 encodes a DRAP1/NC2alpha homolog that has both positive and negative roles in transcription in vivo. Prelich G. Mol Cell Biol, 1997 Apr. PMID 9121454, Free PMC Article
  3. The dual control of TFIIB recruitment by NC2 is gene specific. Masson P, et al. Nucleic Acids Res, 2008 Feb. PMID 18048413, Free PMC Article
  4. Characterization of the basal inhibitor of class II transcription NC2 from Saccharomyces cerevisiae. Goppelt A, et al. Nucleic Acids Res, 1996 Nov 15. PMID 8948634, Free PMC Article
  5. Functional antagonism between RNA polymerase II holoenzyme and global negative regulator NC2 in vivo. Gadbois EL, et al. Proc Natl Acad Sci U S A, 1997 Apr 1. PMID 9096360, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to TBP-class protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables core promoter sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables core promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of negative cofactor 2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of negative cofactor 2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of negative cofactor 2 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
negative cofactor 2 transcription regulator complex subunit BUR6
NP_011086.3
  • Subunit of a heterodimeric NC2 transcription regulator complex; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha; complex also includes Ncb2p; bur6 ncb2 double mutation is functionally complemented by coexpression of human DRAP1 and DR1, although the single bur6 mutation is not complemented by its ortholog DRAP1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    491530..491958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179049.3 → NP_011086.3  TPA: negative cofactor 2 transcription regulator complex subunit BUR6 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011086.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM66, P40096
    UniProtKB/TrEMBL
    A6ZRB6, B3LRS2, B5VHT7, C7GQ37, C8Z7I3, G2WD46, N1P5E8
    Conserved Domains (1) summary
    COG5247
    Location:25 → 142
    BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40096.1

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