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KAP123 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856846, updated on 8-Sep-2024

Summary

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Official Symbol
KAP123
Primary source
SGD:S000000912
Locus tag
YER110C
See related
AllianceGenome:SGD:S000000912; FungiDB:YER110C; VEuPathDB:YER110C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YRB4
Summary
Enables nuclear import signal receptor activity and nuclear localization sequence binding activity. Involved in NLS-bearing protein import into nucleus and regulation of pseudohyphal growth. Located in cytoplasm and nucleus. Orthologous to human IPO4 (importin 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (378762..382103, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene RNA export factor GLE2 Neighboring gene pseudo Neighboring gene SBF complex DNA-binding subunit SWI4 Neighboring gene U6 snRNA complex subunit LSM4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The identification of protein-protein interactions of the nuclear pore complex of Saccharomyces cerevisiae using high throughput matrix-assisted laser desorption ionization time-of-flight tandem mass spectrometry. Huang L, et al. Mol Cell Proteomics, 2002 Jun. PMID 12169684
  2. Simple kinetic relationships and nonspecific competition govern nuclear import rates in vivo. Timney BL, et al. J Cell Biol, 2006 Nov 20. PMID 17116750, Free PMC Article
  3. Yeast chromatin assembly complex 1 protein excludes nonacetylatable forms of histone H4 from chromatin and the nucleus. Glowczewski L, et al. Mol Cell Biol, 2004 Dec. PMID 15542829, Free PMC Article
  4. Regulation of PI4,5P2 synthesis by nuclear-cytoplasmic shuttling of the Mss4 lipid kinase. Audhya A, et al. EMBO J, 2003 Aug 15. PMID 12912920, Free PMC Article
  5. Overexpression of yeast karyopherin Pse1p/Kap121p stimulates the mitochondrial import of hydrophobic proteins in vivo. Corral-Debrinski M, et al. Mol Microbiol, 1999 Mar. PMID 10200968

See all (134) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Suppressors of mRNA Decapping Defects Restore Growth Without Major Effects on mRNA Decay Rates or Abundance.
    Title: Suppressors of mRNA Decapping Defects Restore Growth Without Major Effects on mRNA Decay Rates or Abundance.
  2. combined impairment of lipid and Kap123 binding affects targeting of Pom33 to NPCs. These data highlight the requirement of multiple determinants and mechanisms for proper NPC localization of Pom33.
    Title: Nuclear pore targeting of the yeast Pom33 nucleoporin depends on karyopherin and lipid binding.
  3. The karyopherin Kap123 binds to a nuclear localization sequence next to this amphipathic alpha-helix and prevents unspecific tethering of Nbp1 to membranes.
    Title: Targeting of Nbp1 to the inner nuclear membrane is essential for spindle pole body duplication.
  4. Slt2, the mitogen-activated protein kinase of the protein kinase C cell integrity pathway, is constitutively activated in the absence of Kap123, which is consistent with the existence of cell integrity defects.
    Title: Yeast karyopherins Kap123 and Kap95 are related to the function of the cell integrity pathway.
  5. A role for the karyopherin Kap123p in microtubule stability is reported.
    Title: A role for the karyopherin Kap123p in microtubule stability.
  6. Cac1p and Kap123 cooperate to ensure that only appropriately acetylated histone H4 proteins are imported into the nucleus
    Title: Yeast chromatin assembly complex 1 protein excludes nonacetylatable forms of histone H4 from chromatin and the nucleus.
  7. The Kap123p specifically binds to histones H2A and H2B.
    Title: The histones H2A/H2B and H3/H4 are imported into the yeast nucleus by different mechanisms.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear import signal receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear import signal receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nuclear import signal receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear localization sequence binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in import into nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of pseudohyphal growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule HDA PubMed 
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Kap123p
NP_011035.1
  • Karyopherin beta; mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    378762..382103 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179000.1 → NP_011035.1  TPA: Kap123p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011035.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM16, P40069
    UniProtKB/TrEMBL
    A6ZR65, B3LRM6, B5VHN5, C8Z7C8, G2WD14
    Conserved Domains (2) summary
    smart00913
    Location:25 → 92
    IBN_N; Importin-beta N-terminal domain
    sd00044
    Location:352 → 385
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40069.1

Gene LinkOut

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