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MAM1 Mam1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856843, updated on 18-Sep-2024

Summary

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Official Symbol
MAM1
Official Full Name
Mam1p
Primary source
SGD:S000000908
Locus tag
YER106W
See related
AllianceGenome:SGD:S000000908; FungiDB:YER106W; VEuPathDB:YER106W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in meiotic sister chromatid cohesion involved in meiosis I; monopolar spindle attachment to meiosis I kinetochore; and regulation of protein kinase activity. Located in kinetochore. Part of monopolin complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MAM1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (372326..373234)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Rtt105p Neighboring gene Nup157p Neighboring gene RNA export factor GLE2 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence of Zip1 Promoting Sister Kinetochore Mono-orientation During Meiosis in Budding Yeast. Prajapati HK, et al. G3 (Bethesda), 2018 Nov 6. PMID 30254179, Free PMC Article
  2. Kinetochore orientation during meiosis is controlled by Aurora B and the monopolin complex. Monje-Casas F, et al. Cell, 2007 Feb 9. PMID 17289568, Free PMC Article
  3. Functional genomics identifies monopolin: a kinetochore protein required for segregation of homologs during meiosis i. Tóth A, et al. Cell, 2000 Dec 22. PMID 11163190
  4. Molecular architecture of the yeast monopolin complex. Corbett KD, et al. Cell Rep, 2012 Jun 28. PMID 22813733, Free PMC Article
  5. Spo13 prevents premature cohesin cleavage during meiosis. Galander S, et al. Wellcome Open Res, 2019. PMID 30906881, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Together, the Hrr25 central domain and Mam1 form a novel, contiguous embellishment to the Hrr25 kinase domain that affects Hrr25 conformational dynamics and enzyme kinetics.
    Title: Structure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator.
  2. We show that monopolin subunit Mam1 binds tightly to Hrr25, a highly conserved casein kinase 1 delta/varepsilon, and recruits it to meiosis I centromeres. Hrr25 kinase activity and Mam1 binding are both essential for monopolar attachment.
    Title: Monopolar attachment of sister kinetochores at meiosis I requires casein kinase 1.
  3. Study finds that the Aurora B kinase Ipl1 regulates kinetochore-microtubule attachment during both meiotic divisions and that a complex known as the monopolin complex ensures that the protein kinase coorients sister chromatids during meiosis I.
    Title: Kinetochore orientation during meiosis is controlled by Aurora B and the monopolin complex.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in homologous chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic sister chromatid cohesion involved in meiosis I IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in meiotic sister chromatid cohesion involved in meiosis I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spindle attachment to meiosis I kinetochore IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in spindle attachment to meiosis I kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
part_of monopolin complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mam1p
NP_011032.1
  • Monopolin; meiosis-specific kinetochore-associated protein involved in monopolar attachment of sister kinetochores to the meiotic spindle; subunit of monopolin, a complex that prevents biorientation of sister kinetochores to ensure homolog biorientation during meiosis I; regulates the conformation, enzyme kinetics and substrate specificity of the Dsn1p kinase, Hrr1p; expressed only during the first meiotic division

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    372326..373234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178997.1 → NP_011032.1  TPA: Mam1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011032.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM13, E9P8Y3, P40065
    UniProtKB/TrEMBL
    A6ZR62, C8Z7C4, G2WD17
    Conserved Domains (1) summary
    pfam10434
    Location:4 → 258
    MAM1; Monopolin complex protein MAM1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40065.1

Gene LinkOut

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