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RAD51 recombinase RAD51 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856831, updated on 3-Nov-2024

Summary

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Official Symbol
RAD51
Official Full Name
recombinase RAD51
Primary source
SGD:S000000897
Locus tag
YER095W
See related
AllianceGenome:SGD:S000000897; FungiDB:YER095W; VEuPathDB:YER095W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MUT5
Summary
Enables DNA binding activity and catalytic activity, acting on DNA. Involved in DNA metabolic process and G2/M transition of mitotic cell cycle. Located in condensed nuclear chromosome and mitochondrial matrix. Is active in mitochondrial chromosome. Used to study breast cancer; colorectal cancer; and primary ovarian insufficiency. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group R; breast cancer; congenital mirror movement disorder; and ovarian cancer. Orthologous to human RAD51 (RAD51 recombinase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RAD51 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (349980..351182)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Aim11p Neighboring gene proteasome core particle subunit beta 3 Neighboring gene Shc1p Neighboring gene tRNA-Glu

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of Rad51 inhibits double-strand break-induced homologous recombination but does not affect gene conversion tract lengths. Paffett KS, et al. DNA Repair (Amst), 2005 Jun 8. PMID 15878310
  2. Rad51 protein from the thermotolerant yeast Pichia angusta as a typical but thermodependent member of the Rad51 family. Shalguev VI, et al. Eukaryot Cell, 2004 Dec. PMID 15590830, Free PMC Article
  3. The DNA binding properties of Saccharomyces cerevisiae Rad51 protein. Zaitseva EM, et al. J Biol Chem, 1999 Jan 29. PMID 9915828
  4. Conserved sequence preference in DNA binding among recombination proteins: an effect of ssDNA secondary structure. Biet E, et al. Nucleic Acids Res, 1999 Jan 15. PMID 9862985, Free PMC Article
  5. Base pair switching by interconversion of sugar puckers in DNA extended by proteins of RecA-family: a model for homology search in homologous genetic recombination. Nishinaka T, et al. Proc Natl Acad Sci U S A, 1998 Sep 15. PMID 9736691, Free PMC Article

See all (724) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site.
    Title: Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site.
  2. Yeast Rad52 is a homodecamer and possesses BRCA2-like bipartite Rad51 binding modes.
    Title: Yeast Rad52 is a homodecamer and possesses BRCA2-like bipartite Rad51 binding modes.
  3. Stability of Rad51 recombinase and persistence of Rad51 DNA repair foci depends on post-translational modifiers, ubiquitin and SUMO.
    Title: Stability of Rad51 recombinase and persistence of Rad51 DNA repair foci depends on post-translational modifiers, ubiquitin and SUMO.
  4. Saccharomyces cerevisiae DNA polymerase IV overcomes Rad51 inhibition of DNA polymerase delta in Rad52-mediated direct-repeat recombination.
    Title: Saccharomyces cerevisiae DNA polymerase IV overcomes Rad51 inhibition of DNA polymerase δ in Rad52-mediated direct-repeat recombination.
  5. Bre1/RNF20 promotes Rad51-mediated strand exchange and antagonizes the Srs2/FBH1 helicases.
    Title: Bre1/RNF20 promotes Rad51-mediated strand exchange and antagonizes the Srs2/FBH1 helicases.
  6. Rad51 filaments assembled in the absence of the complex formed by the Rad51 paralogs Rad55 and Rad57 are outcompeted by translesion DNA polymerases on UV-induced ssDNA gaps.
    Title: Rad51 filaments assembled in the absence of the complex formed by the Rad51 paralogs Rad55 and Rad57 are outcompeted by translesion DNA polymerases on UV-induced ssDNA gaps.
  7. Rad51-mediated interhomolog recombination during budding yeast meiosis is promoted by the meiotic recombination checkpoint and the conserved Pif1 helicase.
    Title: Rad51-mediated interhomolog recombination during budding yeast meiosis is promoted by the meiotic recombination checkpoint and the conserved Pif1 helicase.
  8. Repair of mismatched templates during Rad51-dependent Break-Induced Replication.
    Title: Repair of mismatched templates during Rad51-dependent Break-Induced Replication.
  9. Budding yeast Rad51: a paradigm for how phosphorylation and intrinsic structural disorder regulate homologous recombination and protein homeostasis.
    Title: Budding yeast Rad51: a paradigm for how phosphorylation and intrinsic structural disorder regulate homologous recombination and protein homeostasis.
  10. Single-Stranded DNA Curtains for Single-Molecule Visualization of Rad51-ssDNA Filament Dynamics.
    Title: Single-Stranded DNA Curtains for Single-Molecule Visualization of Rad51-ssDNA Filament Dynamics.
Submit: New GeneRIF Correction See all GeneRIFs (89)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent activity, acting on DNA IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA strand exchange activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA strand exchange activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA strand exchange activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA recombinase assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA recombination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA strand invasion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA strand invasion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromosome organization involved in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in heteroduplex formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in meiosis I cell cycle process IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic joint molecule formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic recombination-dependent replication fork processing IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reciprocal meiotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance via recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in condensed nuclear chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrial chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
recombinase RAD51
NP_011021.3
  • Strand exchange protein; forms helical filament with DNA that searches for homology; involved in recombinational repair of DNA DSBs during vegetative growth and meiosis; phosphorylation by Cdc28p in G2/M phase promotes DNA binding, strand invasion, and primer extension; L1 and L2 motifs of DNA binding site I have critical roles in ensuring DNA fidelity during meiotic recombination; RAD51 and RAD4 pathways confer resistance to benzo[a]pyrene dihydrodiol; homolog of Dmc1p and bacterial RecA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    349980..351182
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178986.3 → NP_011021.3  TPA: recombinase RAD51 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011021.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM03, P25454
    UniProtKB/TrEMBL
    A6ZR52, B3LRL4, B5VHM3, C7GRS9, C8Z7B4, G2WCY7
    Conserved Domains (1) summary
    TIGR02239
    Location:83 → 397
    recomb_RAD51; DNA repair protein RAD51
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25454.1

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