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DOT6 Dot6p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856822, updated on 18-Sep-2024

Summary

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Official Symbol
DOT6
Official Full Name
Dot6p
Primary source
SGD:S000000890
Locus tag
YER088C
See related
AllianceGenome:SGD:S000000890; FungiDB:YER088C; VEuPathDB:YER088C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PBF2
Summary
Enables sequence-specific DNA binding activity. Involved in heterochromatin assembly and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of Rpd3L-Expanded complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See DOT6 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (333176..335188, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene putative proline--tRNA ligase AIM10 Neighboring gene Arf family guanine nucleotide exchange factor SBH1 Neighboring gene type 2C protein phosphatase PTC2 Neighboring gene anthranilate synthase TRP2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Microarray profiling of phage-display selections for rapid mapping of transcription factor-DNA interactions. Freckleton G, et al. PLoS Genet, 2009 Apr. PMID 19360118, Free PMC Article
  2. Decoupling Yeast Cell Division and Stress Defense Implicates mRNA Repression in Translational Reallocation during Stress. Ho YH, et al. Curr Biol, 2018 Aug 20. PMID 30078561, Free PMC Article
  3. Protein kinase A and TORC1 activate genes for ribosomal biogenesis by inactivating repressors encoded by Dot6 and its homolog Tod6. Lippman SI, et al. Proc Natl Acad Sci U S A, 2009 Nov 24. PMID 19901341, Free PMC Article
  4. A dynamic model of proteome changes reveals new roles for transcript alteration in yeast. Lee MV, et al. Mol Syst Biol, 2011 Jul 19. PMID 21772262, Free PMC Article
  5. Coordinated regulation of sulfur and phospholipid metabolism reflects the importance of methylation in the growth of yeast. Hickman MJ, et al. Mol Biol Cell, 2011 Nov. PMID 21900497, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results establish Dot6/Tod6 as a direct link between nutrient availability, Ribi gene regulation, and growth control through protein kinase A and TORC1.
    Title: Protein kinase A and TORC1 activate genes for ribosomal biogenesis by inactivating repressors encoded by Dot6 and its homolog Tod6.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding HDA PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in rDNA heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in subtelomeric heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Rpd3L-Expanded complex HDA PubMed 
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm HDA PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Dot6p
NP_011012.3
  • Protein involved in rRNA and ribosome biogenesis; activated in stochastic pulses of nuclear localization; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation; relative distribution to the nucleus increases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    333176..335188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178979.3 → NP_011012.3  TPA: Dot6p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011012.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLZ5, P40059
    UniProtKB/TrEMBL
    G2WCX9
    Conserved Domains (1) summary
    pfam13921
    Location:75 → 125
    Myb_DNA-bind_6; Myb-like DNA-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40059.1

Gene LinkOut

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