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CEM1 fatty acid synthase CEM1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856790, updated on 2-Nov-2024

Summary

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Official Symbol
CEM1
Official Full Name
fatty acid synthase CEM1
Primary source
SGD:S000000863
Locus tag
YER061C
See related
AllianceGenome:SGD:S000000863; FungiDB:YER061C; VEuPathDB:YER061C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable 3-oxoacyl-[acyl-carrier-protein] synthase activity. Predicted to be involved in fatty acid biosynthetic process. Located in mitochondrion. Orthologous to human OXSM (3-oxoacyl-ACP synthase, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CEM1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (278298..279626, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene purine-cytosine permease Neighboring gene purine-cytosine permease Neighboring gene glycerol-1-phosphatase HOR2 Neighboring gene Tho1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a new nuclear gene (CEM1) encoding a protein homologous to a beta-keto-acyl synthase which is essential for mitochondrial respiration in Saccharomyces cerevisiae. Harington A, et al. Mol Microbiol, 1993 Aug. PMID 8412701
  2. Subcellular relocalization of a long-chain fatty acid CoA ligase by a suppressor mutation alleviates a respiration deficiency in Saccharomyces cerevisiae. Harington A, et al. EMBO J, 1994 Dec 1. PMID 7988550, Free PMC Article
  3. Cloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strain. Zhang L, et al. J Biol Chem, 2005 Apr 1. PMID 15668256
  4. Intersection of RNA processing and the type II fatty acid synthesis pathway in yeast mitochondria. Schonauer MS, et al. Mol Cell Biol, 2008 Nov. PMID 18779316, Free PMC Article
  5. The Antifungal Plant Defensin HsAFP1 from Heuchera sanguinea Induces Apoptosis in Candida albicans. Aerts AM, et al. Front Microbiol, 2011. PMID 21993350, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3-oxoacyl-[acyl-carrier-protein] synthase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid biosynthetic process ISA
Inferred from Sequence Alignment
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
fatty acid synthase CEM1
NP_010983.2
  • Mitochondrial beta-keto-acyl synthase; possible role in fatty acid synthesis; required for mitochondrial respiration; human homolog OXSM can complement yeast cem1 null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    278298..279626 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178952.2 → NP_010983.2  TPA: fatty acid synthase CEM1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010983.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLW6, P39525
    UniProtKB/TrEMBL
    A6ZR15, B3LS75, C7GTC9, C8Z767, N1PA42
    Conserved Domains (1) summary
    cd00834
    Location:3 → 436
    KAS_I_II; Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39525.1

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