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FCY2 purine-cytosine permease [ Saccharomyces cerevisiae S288C ]

Gene ID: 856783, updated on 2-Nov-2024

Summary

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Official Symbol
FCY2
Official Full Name
purine-cytosine permease
Primary source
SGD:S000000858
Locus tag
YER056C
See related
AllianceGenome:SGD:S000000858; FungiDB:YER056C; VEuPathDB:YER056C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
BRA7
Summary
Enables cytidine transmembrane transporter activity and nucleobase transmembrane transporter activity. Involved in cytidine transport; cytosine transport; and purine-containing compound transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See FCY2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (266512..268113, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Gip2p Neighboring gene ATP phosphoribosyltransferase Neighboring gene ribosomal 60S subunit protein L34A Neighboring gene putative isoleucine biosynthesis protein HMF1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fluorocytosine causes uncoupled dissipation of the proton gradient and behaves as an imperfect substrate of the yeast cytosine permease. Hopkins P, et al. Yeast, 1992 Dec. PMID 1293884
  2. In vivo phosphorylation of the purine/cytosine permease from the plasma membrane of the yeast Saccharomyces cerevisiae. Pinson B, et al. Eur J Biochem, 1996 Jul 15. PMID 8706752
  3. Cytosine accumulation as a measure of the proton electrochemical gradient acting on the overexpressed cytosine permease of Saccharomyces cerevisiae. Eddy AA, et al. Microbiology (Reading), 1996 Mar. PMID 8868419
  4. Functional analysis of mutated purine-cytosine permease from Saccharomyces cerevisiae. A possible role of the hydrophilic segment 371-377 in the active carrier conformation. Ferreira T, et al. J Biol Chem, 1997 Apr 11. PMID 9092500
  5. Characterization of the Saccharomyces cerevisiae cytosine transporter using energizable plasma membrane vesicles. Pinson B, et al. J Biol Chem, 1997 Nov 14. PMID 9360962

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cytidine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cytidine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nucleobase transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleobase transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytidine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cytidine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytosine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytosine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in purine-containing compound transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
purine-cytosine permease
NP_010976.1
  • Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    266512..268113 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178947.1 → NP_010976.1  TPA: purine-cytosine permease [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010976.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLV9, P17064
    UniProtKB/TrEMBL
    C8Z761
    Conserved Domains (1) summary
    COG1457
    Location:65 → 533
    CodB; Purine-cytosine permease or related protein [Nucleotide transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17064.2

Gene LinkOut

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