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ERG28 Erg28p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856767, updated on 18-Sep-2024

Summary

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Official Symbol
ERG28
Official Full Name
Erg28p
Primary source
SGD:S000000846
Locus tag
YER044C
See related
AllianceGenome:SGD:S000000846; FungiDB:YER044C; VEuPathDB:YER044C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
BUD18
Summary
Enables protein-macromolecule adaptor activity. Involved in demethylation and ergosterol biosynthetic process. Located in endoplasmic reticulum membrane. Orthologous to human ERG28 (ergosterol biosynthesis 28 homolog). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ERG28 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (237570..238016, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene peptide-methionine-S-sulfoxide reductase Neighboring gene adenosylhomocysteinase Neighboring gene Mei4p Neighboring gene Aca1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a consensus motif in Erg28p required for C-4 demethylation in yeast ergosterol biosynthesis based on mutation analysis. Ke X, et al. FEMS Microbiol Lett, 2018 Mar 1. PMID 29319811
  2. The molecular mechanism of a cis-regulatory adaptation in yeast. Chang J, et al. PLoS Genet, 2013. PMID 24068973, Free PMC Article
  3. The ERG28-encoded protein, Erg28p, interacts with both the sterol C-4 demethylation enzyme complex as well as the late biosynthetic protein, the C-24 sterol methyltransferase (Erg6p). Mo C, et al. Biochim Biophys Acta, 2004 Nov 8. PMID 15522820
  4. Actin cytoskeletal inhibitor 19,20-epoxycytochalasin Q sensitizes yeast cells lacking ERG6 through actin-targeting and secondarily through disruption of lipid homeostasis. Watchaputi K, et al. Sci Rep, 2021 Apr 8. PMID 33833332, Free PMC Article
  5. A novel gene conserved from yeast to humans is involved in sterol biosynthesis. Gachotte D, et al. J Lipid Res, 2001 Jan. PMID 11160377

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-macromolecule adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ergosterol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ergosterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Erg28p
NP_010962.1
  • Endoplasmic reticulum membrane protein; may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    237570..238016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178935.1 → NP_010962.1  TPA: Erg28p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010962.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLU4, P40030
    UniProtKB/TrEMBL
    A6ZQZ3, B3LS57, C7GSJ1, C8Z747, G2WCS7, N1P6W7
    Conserved Domains (1) summary
    pfam03694
    Location:21 → 130
    Erg28; Erg28 like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40030.1

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