U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NTF2 Ran GTPase-binding protein NTF2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856727, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
NTF2
Official Full Name
Ran GTPase-binding protein NTF2
Primary source
SGD:S000000811
Locus tag
YER009W
See related
AllianceGenome:SGD:S000000811; FungiDB:YER009W; VEuPathDB:YER009W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables small GTPase binding activity. Involved in protein import into nucleus. Located in nuclear envelope. Human ortholog(s) of this gene implicated in diabetic retinopathy. Orthologous to human NUTF2 (nuclear transport factor 2). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See NTF2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (172115..172492)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene GTP-Rho binding exocyst subunit SEC3 Neighboring gene bifunctional 4-hydroxy-4-methyl-2-oxoglutarate aldolase/oxaloacetate decarboxylase Neighboring gene GPI-anchored mannoprotein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleocytoplasmic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore central transport channel IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Ran GTPase-binding protein NTF2
NP_010925.1
  • Nuclear envelope protein; interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    172115..172492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178900.1 → NP_010925.1  TPA: Ran GTPase-binding protein NTF2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010925.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLQ6, P33331
    UniProtKB/TrEMBL
    A6ZQV6, B3LS21, C7GKI7, C8Z709, G2WCP0, N1P5G2
    Conserved Domains (1) summary
    cd00780
    Location:4 → 123
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33331.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools