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GIM4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856715, updated on 11-Sep-2024

Summary

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Official Symbol
GIM4
Primary source
SGD:S000000729
Locus tag
YEL003W
See related
AllianceGenome:SGD:S000000729; FungiDB:YEL003W; VEuPathDB:YEL003W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PFD2
Summary
Enables tubulin binding activity. Involved in tubulin complex assembly. Located in cytoplasm. Part of prefoldin complex. Orthologous to human PFDN2 (prefoldin subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
2
Sequence:
Chromosome: V; NC_001137.3 (148176..148599)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Vab2p Neighboring gene Yea4p Neighboring gene dolichyl-diphosphooligosaccharide-protein glycotransferase Neighboring gene Irc22p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Absence of Gim proteins, but not GimC complex, alters stress-induced transcription. Amorim AF, et al. Biochim Biophys Acta Gene Regul Mech, 2017 Jul. PMID 28457997
  2. Single-cell profiling screen identifies microtubule-dependent reduction of variability in signaling. Pesce CG, et al. Mol Syst Biol, 2018 Apr 4. PMID 29618636, Free PMC Article
  3. The yeast ubiquitin protease, Ubp3p, promotes protein stability. Brew CT, et al. Genetics, 2002 Nov. PMID 12454057, Free PMC Article
  4. Yeast Sphingolipid Phospholipase Gene ISC1 Regulates the Spindle Checkpoint by a CDC55-Dependent Mechanism. Matmati N, et al. Mol Cell Biol, 2020 May 28. PMID 32205408, Free PMC Article
  5. A distinct P-body-like granule is induced in response to the disruption of microtubule integrity in Saccharomyces cerevisiae. Hurst Z, et al. Genetics, 2022 Aug 30. PMID 35876801, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tubulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in tubulin complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of prefoldin complex IEA
Inferred from Electronic Annotation
more info
  
part_of prefoldin complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
tubulin-binding prefolding complex subunit GIM4
NP_010913.2
  • Subunit of the heterohexameric cochaperone prefoldin complex; complex binds specifically to cytosolic chaperonin and transfers target proteins to it

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    148176..148599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178818.1 → NP_010913.2  TPA: tubulin-binding prefolding complex subunit GIM4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010913.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A2TBP1, D3DLP4, P40005
    UniProtKB/TrEMBL
    C7GKH6, C8Z6Z6, N1P3V9
    Conserved Domains (1) summary
    pfam01920
    Location:9 → 110
    Prefoldin_2; Prefoldin subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40005.2

Gene LinkOut

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