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MAK10 Mak10p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856657, updated on 2-Nov-2024

Summary

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Official Symbol
MAK10
Official Full Name
Mak10p
Primary source
SGD:S000000779
Locus tag
YEL053C
See related
AllianceGenome:SGD:S000000779; FungiDB:YEL053C; VEuPathDB:YEL053C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NAA35
Summary
Contributes to peptide alpha-N-acetyltransferase activity. Involved in N-terminal protein amino acid acetylation and macroautophagy. Located in cytoplasm. Part of NatC complex. Orthologous to human NAA35 (N-alpha-acetyltransferase 35, NatC auxiliary subunit). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MAK10 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (53901..56102, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ribosomal 60S subunit protein L12A Neighboring gene Afg1p Neighboring gene H(+)-transporting V1 sector ATPase subunit D

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MAK10, a glucose-repressible gene necessary for replication of a dsRNA virus of Saccharomyces cerevisiae, has T cell receptor alpha-subunit motifs. Lee YJ, et al. Genetics, 1992 Sep. PMID 1398065, Free PMC Article
  2. Suppression of chromosomal mutations affecting M1 virus replication in Saccharomyces cerevisiae by a variant of a viral RNA segment (L-A) that encodes coat protein. Uemura H, et al. Mol Cell Biol, 1988 Feb. PMID 3280972, Free PMC Article
  3. L-A double-stranded RNA viruslike particle replication cycle in Saccharomyces cerevisiae: particle maturation in vitro and effects of mak10 and pet18 mutations. Fujimura T, et al. Mol Cell Biol, 1987 Jan. PMID 3550421, Free PMC Article
  4. [HOK], a new yeast non-Mendelian trait, enables a replication-defective killer plasmid to be maintained. Wickner RB, et al. Genetics, 1982 Feb. PMID 7049830, Free PMC Article
  5. Two biochemically and genetically different forms of L dsRNA of Saccharomyces cerevisiae exist: One form, L2, is correlated. El-Sherbeini M, et al. Curr Genet, 1983 Mar. PMID 24173120

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to peptide alpha-N-acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-terminal peptidyl-methionine acetylation IEA
Inferred from Electronic Annotation
more info
  
involved_in N-terminal protein amino acid acetylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of NatC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NatC complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NatC complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mak10p
NP_010861.3
  • Non-catalytic subunit of the NatC N-terminal acetyltransferase; required for replication of dsRNA virus; expression is glucose-repressible; human NatC ortholog, Naa35, requires co-expression of the human catalytic subunit, Naa30, to functionally complement the null allele

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    53901..56102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178868.3 → NP_010861.3  TPA: Mak10p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010861.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLJ7, Q02197
    UniProtKB/TrEMBL
    B3LRW5, B5VH84, G2WCI1, N1P549
    Conserved Domains (1) summary
    pfam04112
    Location:35 → 193
    Mak10; Mak10 subunit, NatC N(alpha)-terminal acetyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02197.1

Gene LinkOut

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