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IKI1 Elongator subunit IKI1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856594, updated on 18-Sep-2024

Summary

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Official Symbol
IKI1
Official Full Name
Elongator subunit IKI1
Primary source
SGD:S000001230
Locus tag
YHR187W
See related
AllianceGenome:SGD:S000001230; FungiDB:YHR187W; VEuPathDB:YHR187W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ELP5; HAP2; TOT5
Summary
Contributes to ATP hydrolysis activity and tRNA binding activity. Involved in tRNA modification. Located in cytoplasm and nucleus. Part of elongator holoenzyme complex. Orthologous to human ELP5 (elongator acetyltransferase complex subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See IKI1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (480990..481919)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene tRNA-Val Neighboring gene ubiquitin-binding TORC1 subunit KOG1 Neighboring gene GPI-anchor transamidase subunit GPI16 Neighboring gene aminoacyl-tRNA hydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of IKI1 and IKI3 genes conferring pGKL killer sensitivity on Saccharomyces cerevisiae. Yajima H, et al. Biosci Biotechnol Biochem, 1997 Apr. PMID 9145530
  2. Isolation and genetic characterization of pGKL killer-insensitive mutants (iki) from Saccharomyces cerevisiae. Kishida M, et al. Biosci Biotechnol Biochem, 1996 May. PMID 8704309
  3. Novel domains and orthologues of eukaryotic transcription elongation factors. Ponting CP. Nucleic Acids Res, 2002 Sep 1. PMID 12202748, Free PMC Article
  4. Yeast HAP2 and HAP3: transcriptional activators in a heteromeric complex. Hahn S, et al. Science, 1988 Apr 15. PMID 2832951
  5. A conserved and essential basic region mediates tRNA binding to the Elp1 subunit of the Saccharomyces cerevisiae Elongator complex. Di Santo R, et al. Mol Microbiol, 2014 Jun. PMID 24750273, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to ATP hydrolysis activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to tRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in tRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of elongator holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of elongator holoenzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of elongator holoenzyme complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Elongator subunit IKI1
NP_012057.3
  • Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin; localizes to cytosol, nucleus and peroxisomes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    480990..481919
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179318.3 → NP_012057.3  TPA: Elongator subunit IKI1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012057.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLD5, P38874
    UniProtKB/TrEMBL
    A6ZT93, B3LSU8, B5VKB6, C7GRK9, C8Z9Y6
    Conserved Domains (1) summary
    pfam10483
    Location:11 → 290
    Elong_Iki1; Elongator subunit Iki1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38874.1

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