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OYE2 NADPH dehydrogenase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856584, updated on 18-Sep-2024

Summary

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Official Symbol
OYE2
Official Full Name
NADPH dehydrogenase
Primary source
SGD:S000001222
Locus tag
YHR179W
See related
AllianceGenome:SGD:S000001222; FungiDB:YHR179W; VEuPathDB:YHR179W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables NADPH dehydrogenase activity. Involved in apoptotic process. Located in cytoplasm and nucleus. Colocalizes with mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See OYE2 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (462502..463704)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Rof1p Neighboring gene Stb5p Neighboring gene uncharacterized protein Neighboring gene tRNA-Thr

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Engineering the Enantioselectivity of Yeast Old Yellow Enzyme OYE2y in Asymmetric Reduction of (E/Z)-Citral to (R)-Citronellal. Ying X, et al. Molecules, 2019 Mar 18. PMID 30889828, Free PMC Article
  2. Exploring De Novo metabolic pathways from pyruvate to propionic acid. Stine A, et al. Biotechnol Prog, 2016 Mar. PMID 26821575
  3. Natural allelic variations of Saccharomyces cerevisiae impact stuck fermentation due to the combined effect of ethanol and temperature; a QTL-mapping study. Marullo P, et al. BMC Genomics, 2019 Aug 28. PMID 31462217, Free PMC Article
  4. Engineering the biocatalytic selectivity of iridoid production in Saccharomyces cerevisiae. Billingsley JM, et al. Metab Eng, 2017 Nov. PMID 28939278, Free PMC Article
  5. α,β-Dicarbonyl reduction is mediated by the Saccharomyces Old Yellow Enzyme. van Bergen B, et al. FEMS Yeast Res, 2016 Aug. PMID 27400981

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Three Quantitative Trait Loci linked to stuck fermentation in winemaking conditions were identified by using a selective genotyping strategy carried out on a backcrossed population. The precision of mapping allowed the identification of two causative genes VHS1 and OYE2 characterized by stop-codon insertion.
    Title: Natural allelic variations of Saccharomyces cerevisiae impact stuck fermentation due to the combined effect of ethanol and temperature; a QTL-mapping study.
  2. The results point to the stress-related proteins Ahp1, Yhb1 and Oye2, as well as Gln1 and Kes1 as putative candidates for being evaluated as biomarkers for diagnostic assays of S. cerevisiae infections.
    Title: Immunoproteomic profiling of Saccharomyces cerevisiae systemic infection in a murine model.
  3. OYE proteins are firmly placed in the signaling network connecting ROS generation, PCD modulation, and cytoskeletal dynamics in yeast.
    Title: Old yellow enzymes, highly homologous FMN oxidoreductases with modulating roles in oxidative stress and programmed cell death in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables NADPH dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NADPH dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NADPH dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NADPH dehydrogenase
NP_012049.1
  • Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    462502..463704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179310.1 → NP_012049.1  TPA: NADPH dehydrogenase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012049.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLC8, E9P8V8, Q03558
    UniProtKB/TrEMBL
    A6ZT86, B3LSU1, C7GW80, C8Z9X5, N1P1A6
    Conserved Domains (1) summary
    cd02933
    Location:16 → 372
    OYE_like_FMN; Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03558.3

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