KEL1 Kel1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: KEL1
Official Full Name: Kel1p
Primary source: SGD:S000001201
Locus tag: YHR158C
See related: AllianceGenome:SGD:S000001201; FungiDB:YHR158C; VEuPathDB:YHR158C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in several processes, including negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion; regulation of cell cycle process; and regulation of formin-nucleated actin cable assembly. Located in several cellular components, including cellular bud neck; cellular bud tip; and mating projection tip. Part of Kelch-containing formin regulatory complex. Is active in cytoplasm. Orthologous to human RABEPK (Rab9 effector protein with kelch motifs). [provided by Alliance of Genome Resources, Nov 2024]
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Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

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Bud14, Kel1, and Kel2 interact to form a stable 520-kDa complex that controls actin cable assembly and cell morphogenesis.
Title: Saccharomyces cerevisiae Kelch proteins and Bud14 protein form a stable 520-kDa formin regulatory complex that controls actin cable assembly and cell morphogenesis.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cytogamy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of bipolar cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytokinesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of formin-nucleated actin cable assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Kelch-containing formin regulatory complex	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell cortex of cell tip	IBA Inferred from Biological aspect of Ancestor more info
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud tip	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mating projection tip	HDA more info	PubMed
located_in mating projection tip	IDA Inferred from Direct Assay more info	PubMed
located_in prospore membrane	HDA more info	PubMed

NP_012028.1

Protein required for proper cell fusion and cell morphology; acts as phosphorylation-regulated noise suppressor of pheromone signaling pathway; forms a complex with Bud14p and Kel2p that regulates Bnr1p (formin) to affect actin cable assembly, cytokinesis, and polarized growth; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate

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