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CIA2 iron-sulfur cluster assembly protein CIA2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856522, updated on 18-Sep-2024

Summary

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Official Symbol
CIA2
Official Full Name
iron-sulfur cluster assembly protein CIA2
Primary source
SGD:S000001164
Locus tag
YHR122W
See related
AllianceGenome:SGD:S000001164; FungiDB:YHR122W; VEuPathDB:YHR122W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in iron-sulfur cluster assembly. Located in cytoplasm and nucleus. Part of CIA complex. Orthologous to human CIAO2B (cytosolic iron-sulfur assembly component 2B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CIA2 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (353625..354320)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene mismatch repair ATPase MSH1 Neighboring gene Lsm12p Neighboring gene bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Neighboring gene transcription factor NDT80

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CIA2 deficiency results in impaired oxidative stress response and enhanced intracellular basal UPR activity in Saccharomyces cerevisiae. Zhao W, et al. FEMS Microbiol Lett, 2015 Mar. PMID 25667230
  2. Defining the domains of Cia2 required for its essential function in vivo and in vitro. Vo AT, et al. Metallomics, 2017 Nov 15. PMID 29057997
  3. Identifying the Protein Interactions of the Cytosolic Iron-Sulfur Cluster Targeting Complex Essential for Its Assembly and Recognition of Apo-Targets. Vo A, et al. Biochemistry, 2018 Apr 24. PMID 28539047
  4. Reverse PCA, a systematic approach for identifying genes important for the physical interaction between protein pairs. Lev I, et al. PLoS Genet, 2013. PMID 24130505, Free PMC Article
  5. Production of 1,2,4-butanetriol from xylose by Saccharomyces cerevisiae through Fe metabolic engineering. Bamba T, et al. Metab Eng, 2019 Dec. PMID 31434008

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E208A-iron-sulfur cluster assembly protein CIA2 (Cia2) results in a diminished activity of the cytosolic iron sulfur cluster protein.
    Title: Defining the domains of Cia2 required for its essential function in vivo and in vitro.
  2. results suggest the involvement of Cia2p in oxidative and endoplasmic reticulum stress responses in yeast
    Title: CIA2 deficiency results in impaired oxidative stress response and enhanced intracellular basal UPR activity in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in iron-sulfur cluster assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein maturation by [4Fe-4S] cluster transfer IEA
Inferred from Electronic Annotation
more info
  
involved_in protein maturation by iron-sulfur cluster transfer IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
part_of cytosolic [4Fe-4S] assembly targeting complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
iron-sulfur cluster assembly protein CIA2
NP_011990.1
  • Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation and maturation of a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    353625..354320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179252.1 → NP_011990.1  TPA: iron-sulfur cluster assembly protein CIA2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011990.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL72, P38829
    UniProtKB/TrEMBL
    A6ZT30, B3LSN7, B5VK57, C7GR68, C8Z9R5, N1P156
    Conserved Domains (1) summary
    COG5133
    Location:1 → 231
    COG5133; Uncharacterized conserved protein [Function unknown]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38829.1

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