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MSH1 mismatch repair ATPase MSH1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856520, updated on 2-Nov-2024

Summary

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Official Symbol
MSH1
Official Full Name
mismatch repair ATPase MSH1
Primary source
SGD:S000001162
Locus tag
YHR120W
See related
AllianceGenome:SGD:S000001162; FungiDB:YHR120W; VEuPathDB:YHR120W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ATP-dependent activity, acting on DNA; dinucleotide insertion or deletion binding activity; and guanine/thymine mispair binding activity. Involved in mismatch repair and mitochondrial DNA repair. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MSH1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (349574..352453)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene origin recognition complex subunit 6 Neighboring gene histone methyltransferase SET1 Neighboring gene Lsm12p Neighboring gene iron-sulfur cluster assembly protein CIA2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Purification and characterization of MSH1, a yeast mitochondrial protein that binds to DNA mismatches. Chi NW, et al. J Biol Chem, 1994 Nov 25. PMID 7961998
  2. The effect of DNA mismatches on the ATPase activity of MSH1, a protein in yeast mitochondria that recognizes DNA mismatches. Chi NW, et al. J Biol Chem, 1994 Nov 25. PMID 7961999
  3. A dominant mitochondrial mutator phenotype of Saccharomyces cerevisiae conferred by msh1 alleles altered in the sequence encoding the ATP-binding domain. Koprowski P, et al. Mol Genet Genomics, 2002 Feb. PMID 11862493
  4. Mitochondrial DNA mutators. Foury F, et al. Cell Mol Life Sci, 2004 Nov. PMID 15558210
  5. The yeast MSH1 gene is not involved in DNA repair or recombination during meiosis. Sia EA, et al. DNA Repair (Amst), 2005 Feb 3. PMID 15590333

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that the role of Msh1p in BER is unlikely to be involved in the avoidance of large-scale deletions and rearrangements.
    Title: Evidence that msh1p plays multiple roles in mitochondrial base excision repair.
  2. Msh1p-enhanced homologous recombination may play an important role in the prevention of oxidative lesion-induced rearrangements of the mitochondrial genome.
    Title: Msh1p counteracts oxidative lesion-induced instability of mtDNA and stimulates mitochondrial recombination in Saccharomyces cerevisiae.
  3. The putative recombination genes CCE1, DIN7, and MHR1 have overlapping function with the mismatch repair homolog MSH1 in point mutation avoidance and suppression of aberrant recombination events.
    Title: Overlapping contributions of Msh1p and putative recombination proteins Cce1p, Din7p, and Mhr1p in large-scale recombination and genome sorting events in the mitochondrial genome of Saccharomyces cerevisiae.
  4. MSH1-dependent repair represents a significant back-up to mtBER in the repair of oxidative damage in mtDNA
    Title: Repair of oxidative damage in mitochondrial DNA of Saccharomyces cerevisiae: involvement of the MSH1-dependent pathway.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent activity, acting on DNA IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables dinucleotide insertion or deletion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanine/thymine mispair binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mismatched DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mismatch repair IEA
Inferred from Electronic Annotation
more info
  
involved_in mismatch repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial genome maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mismatch repair ATPase MSH1
NP_011988.1
  • DNA-binding protein of the mitochondria; involved in repair of mitochondrial DNA; has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    349574..352453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179250.1 → NP_011988.1  TPA: mismatch repair ATPase MSH1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011988.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL70, P25846
    UniProtKB/TrEMBL
    B3LSN5, N1P4P5
    Conserved Domains (1) summary
    COG0249
    Location:75 → 958
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25846.2

Gene LinkOut

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