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ORC6 origin recognition complex subunit 6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856518, updated on 2-Nov-2024

Summary

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Official Symbol
ORC6
Official Full Name
origin recognition complex subunit 6
Primary source
SGD:S000001160
Locus tag
YHR118C
See related
AllianceGenome:SGD:S000001160; FungiDB:YHR118C; VEuPathDB:YHR118C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables DNA replication origin binding activity. Involved in DNA replication initiation; pre-replicative complex assembly involved in nuclear cell cycle DNA replication; and silent mating-type cassette heterochromatin formation. Part of DNA replication preinitiation complex; nuclear origin of replication recognition complex; and nuclear pre-replicative complex. Used to study Meier-Gorlin syndrome. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ORC6 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (344321..345628, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Cox23p Neighboring gene protein channel TOM71 Neighboring gene histone methyltransferase SET1 Neighboring gene mismatch repair ATPase MSH1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An essential role for Orc6 in DNA replication through maintenance of pre-replicative complexes. Semple JW, et al. EMBO J, 2006 Nov 1. PMID 17053779, Free PMC Article
  2. Isolation of ORC6, a component of the yeast origin recognition complex by a one-hybrid system. Li JJ, et al. Science, 1993 Dec 17. PMID 8266075
  3. Two-faced cyclins with eyes on the targets. Archambault V, et al. Cell Cycle, 2005 Jan. PMID 15611618
  4. Linkage between phosphorylation of the origin recognition complex and its ATP binding activity in Saccharomyces cerevisiae. Makise M, et al. J Biol Chem, 2009 Feb 6. PMID 19068484
  5. Condensin binding at distinct and specific chromosomal sites in the Saccharomyces cerevisiae genome. Wang BD, et al. Mol Cell Biol, 2005 Aug. PMID 16055730, Free PMC Article

See all (109) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Orc6 RXL/cyclin-binding motif plays a positive role in the initial recruitment of Cdt1/Mcm2-7 to the origin, suggesting that this motif is critical for the switch between active and inhibited ORC function at the G1-to-S-phase transition.
    Title: CDK prevents Mcm2-7 helicase loading by inhibiting Cdt1 interaction with Orc6.
  2. In this study, yeast two-hybrid analysis was used to examine the interaction between Cdt1p and every ORC subunit; potent interaction with Orc6p, and weaker interaction with Orc2p and Orc5p was observed.
    Title: Interaction between ORC and Cdt1p of Saccharomyces cerevisiae.
  3. Orc6 is required for dynamic recruitment of Cdt1 during repeated loading of DNA helicases.
    Title: Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading.
  4. Orc6 was required for entry into S phase after pre-replicative complexes formation
    Title: An essential role for Orc6 in DNA replication through maintenance of pre-replicative complexes.
  5. The 'hydrophobic patch' (HP) of the Saccharomyces cerevisiae S-phase cyclin Clb5 facilitates its interaction with Orc6 (via its Cy or RXL motif), providing a mechanism that helps prevent rereplication from individual origins.
    Title: Two-faced cyclins with eyes on the targets.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA replication origin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pre-replicative complex assembly involved in nuclear cell cycle DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in silent mating-type cassette heterochromatin formation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA replication preinitiation complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear origin of replication recognition complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear origin of replication recognition complex IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear origin of replication recognition complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of nuclear pre-replicative complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
origin recognition complex subunit 6
NP_011986.1
  • Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p; mutation in the human Orc6p is linked to Meier-Gorlin syndrome

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    344321..345628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179248.1 → NP_011986.1  TPA: origin recognition complex subunit 6 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011986.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL68, P38826
    UniProtKB/TrEMBL
    A6ZT26, B3LSN3, C8Z9R1, G2WFJ2, N1P9F4
    Conserved Domains (1) summary
    pfam05460
    Location:22 → 416
    ORC6; Origin recognition complex subunit 6 (ORC6)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38826.2

Gene LinkOut

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