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KIC1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856502, updated on 22-Aug-2024

Summary

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Official Symbol
KIC1
Primary source
FungiDB:YHR102W
Locus tag
YHR102W
See related
SGD:S000001144; AllianceGenome:SGD:S000001144; VEuPathDB:YHR102W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NRK1
Summary
Enables protein kinase activity. Involved in budding cell apical bud growth and fungal-type cell wall organization. Located in cellular bud and mating projection tip. Part of incipient cellular bud site. Orthologous to human STK26 (serine/threonine kinase 26). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (316572..319814)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene phosphatidylglycerophosphatase Neighboring gene Big1p Neighboring gene Sbe22p Neighboring gene trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+))

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cell cycle regulated interaction of a yeast Hippo kinase and its activator MO25/Hym1. Hsu J, et al. PLoS One, 2013. PMID 24205201, Free PMC Article
  2. Fine structure analysis of the yeast centrin, Cdc31p, identifies residues specific for cell morphology and spindle pole body duplication. Ivanovska I, et al. Genetics, 2001 Feb. PMID 11156974, Free PMC Article
  3. The yeast centrin, cdc31p, and the interacting protein kinase, Kic1p, are required for cell integrity. Sullivan DS, et al. J Cell Biol, 1998 Nov 2. PMID 9813095, Free PMC Article
  4. Genome-wide association analysis of clinical vs. nonclinical origin provides insights into Saccharomyces cerevisiae pathogenesis. Muller LA, et al. Mol Ecol, 2011 Oct. PMID 21880084, Free PMC Article
  5. Roles of the RAM signaling network in cell cycle progression in Saccharomyces cerevisiae. Bogomolnaya LM, et al. Curr Genet, 2006 Jun. PMID 16552603

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in budding cell apical bud growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in budding cell apical bud growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cellular bud IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mating projection tip IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
putative serine/threonine protein kinase KIC1
NP_011970.1
  • Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; phosphorylates Cbk1p kinase after allosteric activation by Hym1p; part of the RAM network that regulates cellular polarity and morphogenesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    316572..319814
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179232.1 → NP_011970.1  TPA: putative serine/threonine protein kinase KIC1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011970.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL52, P38692
    UniProtKB/TrEMBL
    B3LSL7, N1P4M5
    Conserved Domains (1) summary
    cd06917
    Location:21 → 295
    STKc_NAK1_like; Catalytic domain of Fungal Nak1-like Serine/Threonine Kinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38692.1

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