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BIG1 Big1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856501, updated on 14-Nov-2024

Summary

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Official Symbol
BIG1
Official Full Name
Big1p
Primary source
SGD:S000001143
Locus tag
YHR101C
See related
AllianceGenome:SGD:S000001143; FungiDB:YHR101C; VEuPathDB:YHR101C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in fungal-type cell wall biogenesis. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See BIG1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
2
Sequence:
Chromosome: VIII; NC_001140.6 (314874..315968, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene histone acetyltransferase TRA1 Neighboring gene phosphatidylglycerophosphatase Neighboring gene putative serine/threonine protein kinase KIC1 Neighboring gene Sbe22p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deletion of BIG1 does not affect the rate of vegetative growth but does lead to defects in filamentation, adhesion, and virulence in the kidneys of infected mice.
    Title: Deletion of the CaBIG1 gene reduces beta-1,6-glucan synthesis, filamentation, adhesion, and virulence in Candida albicans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in (1->6)-beta-D-glucan biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in (1->6)-beta-D-glucan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vacuolar proton-transporting V-type ATPase complex assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within vacuolar proton-transporting V-type ATPase complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vacuolar proton-transporting V-type ATPase complex assembly IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Big1p
NP_011969.1
  • Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    314874..315968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179231.1 → NP_011969.1  TPA: Big1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011969.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL51, P38813
    UniProtKB/TrEMBL
    A6ZT09, B3LSL6, C8Z9P4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38813.1

Gene LinkOut

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