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RRP4 exosome non-catalytic core subunit RRP4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856466, updated on 18-Sep-2024

Summary

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Official Symbol
RRP4
Official Full Name
exosome non-catalytic core subunit RRP4
Primary source
SGD:S000001111
Locus tag
YHR069C
See related
AllianceGenome:SGD:S000001111; FungiDB:YHR069C; VEuPathDB:YHR069C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable RNA binding activity. Involved in RNA metabolic process. Part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Orthologous to human EXOSC2 (exosome component 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RRP4 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (233579..234658, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene hydroxyacyl-thioester dehydratase HTD2 Neighboring gene deoxyhypusine synthase Neighboring gene tRNA (guanine) methyltransferase Neighboring gene Pcl5p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNA channelling by the eukaryotic exosome. Malet H, et al. EMBO Rep, 2010 Dec. PMID 21072061, Free PMC Article
  2. Insight into the RNA Exosome Complex Through Modeling Pontocerebellar Hypoplasia Type 1b Disease Mutations in Yeast. Fasken MB, et al. Genetics, 2017 Jan. PMID 27777260, Free PMC Article
  3. Structural and biochemical characterization of the yeast exosome component Rrp40. Oddone A, et al. EMBO Rep, 2007 Jan. PMID 17159918, Free PMC Article
  4. Dob1p (Mtr4p) is a putative ATP-dependent RNA helicase required for the 3' end formation of 5.8S rRNA in Saccharomyces cerevisiae. de la Cruz J, et al. EMBO J, 1998 Feb 16. PMID 9463390, Free PMC Article
  5. Expanding the definition of the classical bipartite nuclear localization signal. Lange A, et al. Traffic, 2010 Mar. PMID 20028483, Free PMC Article

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A budding yeast model for human disease mutations in the EXOSC2 cap subunit of the RNA exosome complex.
    Title: A budding yeast model for human disease mutations in the EXOSC2 cap subunit of the RNA exosome complex.
  2. The three cap proteins (Csl4, Rrp4 and Rrp40) and the nuclease (Rrp44) are multidomain proteins with the expected conformational variability.
    Title: Structure determination of an 11-subunit exosome in complex with RNA by molecular replacement.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in CUT catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in TRAMP-dependent tRNA surveillance pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in TRAMP-dependent tRNA surveillance pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in U4 snRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in U4 snRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear mRNA surveillance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nuclear polyadenylation-dependent rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear polyadenylation-dependent rRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear-transcribed mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in poly(A)-dependent snoRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in poly(A)-dependent snoRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic exosome (RNase complex) IDA
Inferred from Direct Assay
more info
 PubMed 
part_of exosome (RNase complex) IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear exosome (RNase complex) IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
exosome non-catalytic core subunit RRP4
NP_011936.1
  • Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; mutations in the human ortholog, EXOSC2, cause SHRF (Short stature, Hearing loss, Retinitis pigmentosa and distinctive Facies) syndrome, an RNA exosomopathy

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    233579..234658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179199.1 → NP_011936.1  TPA: exosome non-catalytic core subunit RRP4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011936.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL18, P38792
    UniProtKB/TrEMBL
    A6ZSX5, B3LSI7, B5VJZ7, C7GWT0, C8Z9K7, G2WFE1, N1P4J2
    Conserved Domains (1) summary
    COG1097
    Location:45 → 316
    Rrp4; Exosome complex RNA-binding protein Rrp4, contains S1 and KH domains [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38792.1

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