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GIC1 Gic1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856458, updated on 3-Nov-2024

Summary

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Official Symbol
GIC1
Official Full Name
Gic1p
Primary source
SGD:S000001103
Locus tag
YHR061C
See related
AllianceGenome:SGD:S000001103; FungiDB:YHR061C; VEuPathDB:YHR061C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables small GTPase binding activity. Involved in several processes, including Cdc42 protein signal transduction; regulation of exit from mitosis; and septin ring organization. Located in several cellular components, including cellular bud tip; incipient cellular bud site; and mating projection tip. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See GIC1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (221534..222478, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene mitochondrial 37S ribosomal protein FYV4 Neighboring gene Vma22p Neighboring gene RNA-binding RNA processing protein RPP1 Neighboring gene 2-dehydropantoate 2-reductase PAN5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of Cdc42 and Gic1 in the regulation of septin filament formation and dissociation. Sadian Y, et al. Elife, 2013 Nov 28. PMID 24286829, Free PMC Article
  2. The Cdc42 effectors Gic1 and Gic2 regulate polarized post-Golgi secretion. Liu Y, et al. Cell Biosci, 2019. PMID 30988896, Free PMC Article
  3. A role for Gic1 and Gic2 in Cdc42 polarization at elevated temperature. Daniels CN, et al. PLoS One, 2018. PMID 30566437, Free PMC Article
  4. Novel Cdc42-binding proteins Gic1 and Gic2 control cell polarity in yeast. Brown JL, et al. Genes Dev, 1997 Nov 15. PMID 9367980, Free PMC Article
  5. Daughter cell identity emerges from the interplay of Cdc42, septins, and exocytosis. Okada S, et al. Dev Cell, 2013 Jul 29. PMID 23906065, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In yeast cells, Cdc42 polarization involves a positive feedback loop in which effectors called p21-activated kinases (PAKs) act to recruit a Cdc42-directed guanine nucleotide exchange factor (GEF), generating more GTP-Cdc42 in areas that already have GTP-Cdc42. The GTPase-interacting components (GICs) Gic1 and Gic2 are also Cdc42 effectors, and have been implicated in regulation of the actin and septin cytoskeleton.
    Title: A role for Gic1 and Gic2 in Cdc42 polarization at elevated temperature.
  2. we performed domain analysis to identify domain(s) of Gic1 that are important for its boundary activity, and identified two minimum domains, which are located outside its Cdc42-binding domain.
    Title: Gic1 is a novel heterochromatin boundary protein in vivo.
  3. we have used electron microscopy and cryo electron tomography to elucidate the structural basis of the Gic1-septin and Gic1-Cdc42-septin interaction
    Title: The role of Cdc42 and Gic1 in the regulation of septin filament formation and dissociation.
  4. High-copy GIC1 suppresses the growth defect of a PKC1 mutant (stt1), suggesting the existence of a Pkc1-Zds1-Gic1 pathway.
    Title: Pkc1 acts through Zds1 and Gic1 to suppress growth and cell polarity defects of a yeast eIF5A mutant.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Cdc42 protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in establishment of cell polarity IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of exit from mitosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in septin ring organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in septin ring organization IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud tip HDA PubMed 
located_in cellular bud tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud tip IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mating projection tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
Gic1p
NP_011928.1
  • Rho-family GTPase interacting protein and Cdc42p effector; required with Gic2p for polarity establishment and initiation of budding; involved in recruitment of septins to the presumptive bud site; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain; gic1 gic2 double mutants are defective for polarizing Cdc42p at elevated temperature, so may function both up- and downstream of Cdc42p; regulates mitotic exit; relocalizes from bud neck to nucleus upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    221534..222478 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179191.1 → NP_011928.1  TPA: Gic1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011928.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL10, P38785
    UniProtKB/TrEMBL
    A6ZSW7, C7GTX2, G2WFD3, N1P231
    Conserved Domains (1) summary
    cd00132
    Location:124 → 162
    CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38785.1

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